Evidence map›Paper›PMID 38075026›Full record

ArticleNeurobiology of stress2024

Microglia are necessary for probiotics supplementation to improve impaired fear extinction caused by pregnancy stress in adult offspring of rats.

Ru Zeng, Jie Chen, Yihan Peng, Weiye Xu, Yuanyuan Tao, Min Li, Ruqi Zhang, Jingzhuo Meng, Zhiyuan Li, Leping Zeng and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of stress, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Gut microbes · 2026
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ru ZengDepartment of Anatomy and Neurobiology, School of Basic Medical Sciences, Central South University, 138th Tongzipo Road, Changsha, Hunan, 410013, China.
Jie ChenDepartment of Anatomy and Neurobiology, School of Basic Medical Sciences, Central South University, 138th Tongzipo Road, Changsha, Hunan, 410013, China.
Yihan PengDepartment of Anatomy and Neurobiology, School of Basic Medical Sciences, Central South University, 138th Tongzipo Road, Changsha, Hunan, 410013, China.
Weiye XuDepartment of Anatomy and Neurobiology, School of Basic Medical Sciences, Central South University, 138th Tongzipo Road, Changsha, Hunan, 410013, China.
Yuanyuan TaoDepartment of Anatomy and Neurobiology, School of Basic Medical Sciences, Central South University, 138th Tongzipo Road, Changsha, Hunan, 410013, China.
Min LiDepartment of Anatomy and Neurobiology, School of Basic Medical Sciences, Central South University, 138th Tongzipo Road, Changsha, Hunan, 410013, China.
Ruqi ZhangDepartment of Anatomy and Neurobiology, School of Basic Medical Sciences, Central South University, 138th Tongzipo Road, Changsha, Hunan, 410013, China.
Jingzhuo MengDepartment of Anatomy and Neurobiology, School of Basic Medical Sciences, Central South University, 138th Tongzipo Road, Changsha, Hunan, 410013, China.
Zhiyuan LiDepartment of Anatomy and Neurobiology, School of Basic Medical Sciences, Central South University, 138th Tongzipo Road, Changsha, Hunan, 410013, China.
Leping ZengDepartment of Anatomy and Neurobiology, School of Basic Medical Sciences, Central South University, 138th Tongzipo Road, Changsha, Hunan, 410013, China.
Jufang HuangDepartment of Anatomy and Neurobiology, School of Basic Medical Sciences, Central South University, 138th Tongzipo Road, Changsha, Hunan, 410013, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The prevention and treatment of fear-related disorders in offspring affected by pregnancy stress remains challenging at clinic. Here, we examined the effects of gut microbiota of stressed pregnant rats on the fear extinction of their offsprings, and the potential mechanisms. We found that gut microbiota transplantation from rats with pregnancy stress to normal pregnant rats impaired fear extinction, induced microglial activation and synaptic phagocytosis, increased synapse loss in offsprings. Probiotics supplement during pregnancy stress partly normalized pregnancy stress-induced gut microbiota dysbiosis of pregnant rats, and promoted fear memory extinction, inhibited fear memory reappearance, and limited microglial activation and synaptic phagocytosis in offsprings. These data revealed that gut microbiota of stressed pregnant mother improved the development of fear-related disorders of offspring, which may be associated with microglial synaptic pruning.

Indexed as

Fear extinctionGut microbiotaMicrogliaPregnancy stressProbiotics

Identifiers

PMID38075026
PMCPMC10709091

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.