Evidence map›Paper›PMID 38074984›Full record

ArticleNano energy2020

Biodegradable Nanofiber Bone-Tissue Scaffold as Remotely-Controlled and Self-Powering Electrical Stimulator.

Ritopa Das, Eli J Curry, Thinh T Le, Guleid Awale, Yang Liu, Shunyi Li, Joemart Contreras, Casey Bednarz, Jayla Millender, Xiaonan Xin and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nano energy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 166 citations in OpenAlex.

  1. Article
  2. Mastication-Induced Electrical Stimulation Activates Prg4Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  3. Article
  4. Review
  5. Alveolar Bone Regeneration: Smart Biomaterials and Physical Stimulation.Journal of biomedical materials research. Part B, Applied biomaterials · 2026
    Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Open Challenges and Opportunities in Piezoelectricity for Tissue Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  17. Article
  18. Biodegradable Medical Implants: Reshaping Future Medical Practice.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  19. Review
  20. Piezoelectric Biomaterials for Bone Regeneration: Roadmap from Dipole to Osteogenesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Ritopa DasDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USA.
Eli J CurryDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USA.
Thinh T LeDepartment of Mechanical Engineering, University of Connecticut, Storrs, CT 06269, USA.
Guleid AwaleDepartment of Chemical and Biomolecular Engineering, University of Connecticut, Storrs, CT 06269, USA.
Yang LiuDepartment of Mechanical Engineering, University of Connecticut, Storrs, CT 06269, USA.
Shunyi LiDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USA.
Joemart ContrerasDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USA.
Casey BednarzDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, CT 06269, USA.
Jayla MillenderDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, CT 06269, USA.
Xiaonan XinCenter for Regenerative Medicine and Skeletal Development, School of Dental Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA.
David RoweCenter for Regenerative Medicine and Skeletal Development, School of Dental Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA.
Sharareh EmadiDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USA.
Kevin W-H LoThe Connecticut Convergence Institute for Translation in Regenerative Engineering, University of Connecticut Health Center, Farmington, CT 06030.
Thanh D NguyenDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USA.
University of Connecticut · USUConn Health · US

Funding

Bionic Self-Stimulated Cartilage R21EB024787R21EB024787 · NIBIB · UNIVERSITY OF CONNECTICUT STORRS · PI NGUYEN, THANH · 2017 to 2020
$797k
Biodegradable ultrasonic transducer for blood-brain drug-deliveryR21NS116095 · NINDS · UNIVERSITY OF CONNECTICUT STORRS · PI NGUYEN, THANH, PACHTER, JOEL S · 2020 to 2020
$444k
The Molecular Mechanism of the Surface Charge of Piezoelectric Materials for Bone Regenerative EngineeringR21AR075133 · NIAMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI LO, WAI HONG · 2020 to 2021
$402k
Biodegradable Piezoelectric Scaffold for Bone regenerationR21AR075196 · NIAMS · UNIVERSITY OF CONNECTICUT STORRS · PI NGUYEN, THANH · 2019 to 2020
$389k
NIAMS NIH HHS R21 AR075133NIAMS NIH HHS R21 AR075196NIBIB NIH HHS R21 EB024787NINDS NIH HHS R21 NS116095
6 · The paper itself

Abstract

Electrical stimulation (ES) has been shown to induce and enhance bone regeneration. By combining this treatment with tissue-engineering approaches (which rely on biomaterial scaffolds to construct artificial tissues), a replacement bone-graft with strong regenerative properties can be achieved while avoiding the use of potentially toxic levels of growth factors. Unfortunately, there is currently a lack of safe and effective methods to induce electrical cues directly on cells/tissues grown on the biomaterial scaffolds. Here, we present a novel bone regeneration method which hybridizes ES and tissue-engineering approaches by employing a biodegradable piezoelectric PLLA (Poly(L-lactic acid)) nanofiber scaffold which, together with externally-controlled ultrasound (US), can generate surface-charges to drive bone regeneration. We demonstrate that the approach of using the piezoelectric scaffold and US can enhance osteogenic differentiation of different stem cells

Indexed as

Biodegradable piezoelectric nanofibersBone regenerationelectrical stimulationTissue engineeringultrasound

Identifiers

PMID38074984
PMCPMC10703347
OpenAlexW3037295900

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.