ArticleAmerican journal of translational research2023
Ameliorative effects of allogeneic and xenogenic bone marrow-derived mesechymal stem cells on carbon tetrachloride-induced rat liver injury and cirrhosis via modulation of oxidative stress, apoptosis, inflammation, and Nrf2 expression.
Article in American journal of translational research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed, 3 citations in OpenAlex.
- Activation of Nrf2 with natural flavonoids and mesenchymal stromal/stem cells: mechanisms and therapeutic potential for inflammatory diseases.Stem cell research & therapy · 2026Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe aim of this study was to compare the effects of bone marrow-derived mesenchymal stem cells (BM-MSCs) isolated from mice (xenogeneic) and rats (allogeneic) on liver injury induced by carbon tetrachloride (CCl4) as well as to explore the modulatory effects on of oxidative stress, apoptosis, inflammation, and Nrf2 expression.
methodsMale Wistar rats were intraperitoneally injected with CCl4 (0.5 mL/kg) twice a week for 8 weeks. The animals were intravenously infused with BM-MSCs isolated from male mice or rats (1 × 10
resultsThe treatment with BM-MSCs produced a significant increase in the diminished serum albumin level, a significant decrease in liver lipid peroxidation and an increase in glutathione content as well as SOD, GST, and GPx activities. Furthermore, BM-MSCs from both mice and rats produced a significant decrease in the elevated mRNA expression of liver CYP1A1, MMP-9, procollagen α1, TGF-β1, and increase in expression of lowered IL-4, IL-10, cluster CD-105, and Oct3/4. In liver of CCl4-injected rats, the lower protein expression of Nrf2 was upregulated and higher expressions of caspase-3, TNF-R1, NF-κB p65, TNF-α, p53, and COX-2 were downregulated by mice and rats' BM-MSCs. Histologically, BM-MSCs from both mice and rats successfully improved liver structural integrity and protected against liver injury.
conclusionsThe rats-derived BM-MSCs were significantly more potent than mice-derived BM-MSCs. Mice BM-MSCs and rats' BM-MSCs acted to improve CCl4-impaired liver function, structural integrity, fibrosis and cirrhosis in male Wistar rats
Indexed as
Identifiers
38074814PMC10703665W4389800750What OpenQuestion holds
Registered trials
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