Evidence map›Paper›PMID 38074769›Full record

SynthesisFrontiers in public health2023

The impact of diabetes mellitus on the emergence of multi-drug resistant tuberculosis and treatment failure in TB-diabetes comorbid patients: a systematic review and meta-analysis.

Anees Ur Rehman, Mahnoor Khattak, Usman Mushtaq, Muhammad Latif, Imran Ahmad, Muhammad Fawad Rasool, Sadia Shakeel, Khezar Hayat, Rabia Hussain, Ghaidaa Ali Alhazmi and 7 more

Open access · goldAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Frontiers in public health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 4 pooled it
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 4 syntheses or guidelines pooled it, 39 citations in OpenAlex.

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  11. Influence of Diabetes Mellitus on the Development of Multidrug-Resistant Tuberculosis (MDR-TB) in Relation With Genetic Mutations ofThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 12 institutions in 3 countries.

Anees Ur Rehman *Department of Pharmacy Practice, Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan.
Mahnoor Khattak *Department of Pharmacy Practice, Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan.
Usman MushtaqNishter Medical University and Hospital, Multan, Pakistan.
Muhammad LatifDepartment of Zoology, Division of Science and Technology, University of Education Lahore, Lahore, Pakistan.
Imran AhmadDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan.
Muhammad Fawad RasoolDepartment of Pharmacy Practice, Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan.
Sadia ShakeelDepartment of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Dow University of Health Sciences, Karachi, Pakistan.
Khezar HayatInstitute of Pharmaceutical Sciences, University of Veterinary and Animal Sciences, Lahore, Pakistan.
Rabia HussainSchool of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia.
Ghaidaa Ali AlhazmiDepartment of Pharmacy, King Abdullah Medical City, Ministry of Health, Makkah, Saudi Arabia.
Afnan Owedah AlshomraniPharmaceutical Care Department, King Abdulaziz Medical City, Ministry of National Guard - Health Affairs, Jeddah, Saudi Arabia.
Mohammed Ibrahim AlalawiInternal Medicine Department, Alnoor Specialist Hospital, Makkah, Saudi Arabia.
Saleh AlghamdiDepartment of Clinical Pharmacy, Faculty of Pharmacy, Al-Baha University, Al-Baha, Saudi Arabia.
Mohammad Tarique ImamDepartment of Clinical Pharmacy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al Kharj, Saudi Arabia.
Safa S Almarzoky AbuhussainDepartment of Pharmacy Practice, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia.
Sarah M KhayyatDepartment of Pharmacy Practice, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia.
Abdul Haseeb *Department of Pharmacy Practice, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia.
Bahauddin Zakariya University · PKUmm al-Qura University · SAAl Baha University · SADow University of Health Sciences · PKMinistry of Health · SANational Guard Health Affairs · SANishtar Medical College and Hospital · PKPrince Sattam Bin Abdulaziz University · SASaad Specialist Hospital · SAUniversiti Sains Malaysia · MYUniversity of Okara · PKUniversity of Veterinary and Animal Sciences · PK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The existence of Type 2 Diabetes Mellitus (DM) in tuberculosis (TB) patients is very dangerous for the health of patients. One of the major concerns is the emergence of MDR-TB in such patients. It is suspected that the development of MDR-TB further worsens the treatment outcomes of TB such as treatment failure and thus, causes disease progression. Aim: To investigate the impact of DM on the Emergence of MDR-TB and Treatment Failure in TB-DM comorbid patients. Methodology: The PubMed database was systematically searched until April 03, 2022 (date last searched). Thirty studies met the inclusion criteria and were included in this study after a proper selection process. Results: Tuberculosis-Diabetes Mellitus patients were at higher risk to develop MDR-TB as compared to TB-non-DM patients (HR 0.81, 95% CI: 0.60-0.96, Conclusion: The results showed that DM had a significant impact on the emergence of MDR-TB in TB-diabetes comorbid patients as compared to TB-non-DM patients. DM enhanced the risk of TB treatment failure rates in TB-diabetes patients as compared to TB-non-DM patients. Our study highlights the need for earlier screening of MDR-TB, thorough MDR-TB monitoring, and designing proper and effective treatment strategies to prevent disease progression.

Indexed as

Diabetes Mellitus, Type 2Tuberculosis, Multidrug-ResistantComorbidityDisease ProgressionHumansTreatment Failurediabetes mellitusdisease progressionmulti-drug resistant TBTB-DM comorbiditytreatment failuretuberculosis

Identifiers

PMID38074769
PMCPMC10704033
OpenAlexW4388735450

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.