ArticleJournal of biomedical optics2023
Improved spatial speckle contrast model for tissue blood flow imaging: effects of spatial correlation among neighboring camera pixels.
Article in Journal of biomedical optics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Laser speckle imaging for biofilm viability assessment: a noninvasive alternative to the MTT assay.Biomedical optics express · 2026Article
- Improved temporal speckle contrast model for slow and fast dynamic: effect of temporal correlation among neighboring pixels.Journal of biomedical optics · 2025Article
- Laser speckle size and contrast investigation of volumetric scattering from controlled turbid phantoms and mouse skin tissues.iScience · 2025Article
- Time-Resolved Laser Speckle Contrast Imaging (TR-LSCI) of Cerebral Blood Flow.IEEE transactions on medical imaging · 2025Article
- Improvements and validation of spatiotemporal speckle correlation model for rolling shutter speckle imaging.Biomedical optics express · 2024Article
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Authors and funding
6 authors.
Funding
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Abstract
Significance: Speckle contrast analysis is the basis of laser speckle imaging (LSI), a simple, inexpensive, noninvasive technique used in various fields of medicine and engineering. A common application of LSI is the measurement of tissue blood flow. Accurate measurement of speckle contrast is essential to correctly measure blood flow. Variables, such as speckle grain size and camera pixel size, affect the speckle pattern and thus the speckle contrast. Aim: We studied the effects of spatial correlation among adjacent camera pixels on the resulting speckle contrast values. Approach: We derived a model that accounts for the potential correlation of intensity values in the common experimental situation where the speckle grain size is larger than the camera pixel size. Results: Our spatial correlation model predicts that speckle contrast first increases, then decreases as the speckle grain size increases relative to the pixel size. This decreasing trend opposes what is observed with a standard speckle contrast model that does not consider spatial correlation. Experimental data are in good agreement with the predictions of our spatial correlation model. Conclusions: We present a spatial correlation model that provides a more accurate measurement of speckle contrast, which should lead to improved accuracy in tissue blood flow measurements. The associated correlation factors only need to be calculated once, and open-source software is provided to assist with the calculation.
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