ReviewJournal of orthopaedics2024
Neuromodulators can promote nerve regeneration and accelerate functional recovery after peripheral nerve injury: A systematic review.
Review in Journal of orthopaedics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.
- Application of Medicinal Mushrooms for the Treatment of Peripheral Nerve Injury: A Systematic Review.Medical sciences (Basel, Switzerland) · 2026Pooled it
- Optimization of the Missouri Osteochondral Preservation System for the storage of peripheral nerve allografts.JPRAS open · 2026Article
- Surgical excision of an infraorbital nerve schwannoma via a transconjunctival approach with lateral canthotomy: a case report.Frontiers in oral health · 2026Article
- Electrical Stimulation and Platelet-Rich Plasma as Complementary Approaches for Peripheral Nerve Regeneration.Cellular and molecular neurobiology · 2025Review
- Insights into Advances and Applications of Biomaterials for Nerve Tissue Injuries and Neurodegenerative Disorders.Macromolecular bioscience · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Peripheral nerve injuries (PNIs) are debilitating injuries that are also challenging to treat. With several different techniques being investigated to optimize nerve regeneration, we performed this systematic review aiming to evaluate and synthesize the available peer-reviewed literature regarding PNIs and the research that has been done to optimize peripheral nerve regeneration. Two research databases were searched, and abstracts were reviewed for relevance. The abstracts that met screening criteria then underwent full-text review. Out of 6,128 unique citations, 164 publications were ultimately included in this review. Evidence supports many potential options for the management of PNIs, including surgical treatment and systemic and local administration of various pharmacological agents. Some of the reported benefits of treatment with such agents include faster nerve regeneration, improved functional recovery, neuroma prevention, and decreased scar formation. However, much of the research reviewed has been performed in animal models, not human trails. Additionally, the safety profile of some agents makes systemic treatment difficult. Further translational and clinical studies are needed to fill these remaining gaps in knowledge to make evidence-based recommendations regarding the most effective treatment for PNIs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.