ReviewFrontiers in pharmacology2023
Intermittent hypoxia: linkage between OSAS and epilepsy.
Review in Frontiers in pharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 8 citations in OpenAlex.
- Burden of Sleep Disturbances and Sleep Apnea Risk Among Children with Epilepsy: A Case-Control Study.Journal of epidemiology and global health · 2026Article
- Narcolepsy-like presentations in intellectual disability with comorbid epilepsy and obstructive sleep apnea: a case-based diagnostic analysis and literature-informed discussion.Frontiers in psychiatry · 2026Article
- Refuting a Temporal Correlation: Interictal Epileptic Discharges Do Not Preferentially Occur During Respiratory Events in Patients With Sleep-Related Breathing Disorder and Epilepsy.Journal of sleep research · 2025Article
- Depression in older adults with epilepsy: Pathophysiology and management considerations.Epilepsy & behavior : E&B · 2025Review
- Etiological diagnosis of late-onset epilepsy: A key priority for Italian epileptologists - Insights from a LICE survey.Epilepsia open · 2025Article
- The hidden rhythms of epilepsy: exploring biological clocks and epileptic seizure dynamics.Acta epileptologica · 2025Review
- Correlation of telomere length and DNA damage markers with severity and associated depressive states in patients with OSAS.Frontiers in neurology · 2025Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obstructive sleep apnea syndrome (OSAS) refers to the current apnea during sleep caused by upper airway collapse. Meanwhile, epilepsy is a common neurological disorder with a tendency for spontaneous and persistent seizures. Accumulating evidence indicates that OSAS was not independent of epilepsy. Patients with OSAS were observed to be susceptible to epilepsy, while OSAS could decrease the seizure threshold in epilepsy. However, the mechanisms underlying the association of OSAS with epilepsy have not been fully understood. In this study, we propose that intermittent hypoxia, common among OSAS patients due to upper airway collapse, is the linkage between OSAS and epilepsy. Intermittent hypoxia induces elevated levels of oxidative stress and inflammation, potentially causing excessive inflammatory and endoplasmic reticulum stress in brain tissue, which might ultimately lead to the development of epilepsy. Therapeutic approaches targeting inflammation and oxidative stress may provide novel insights into the treatment of OSAS and epilepsy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.