ReviewFrontiers in pharmacology2023
Research progress in cardiotoxicity of organophosphate esters.
Review in Frontiers in pharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 4 citations in OpenAlex.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Organophosphate esters (OPEs) have been extensively utilized worldwide as a substitution for brominated flame retardants. With an increased awareness of the need for environmental protection, the potential health risks and ecological hazards of OPEs have attracted widespread attention. As the dynamic organ of the circulatory system, the heart plays a significant role in maintaining normal life activities. Currently, there is a lack of systematic appraisal of the cardiotoxicity of OPEs. This article summarized the effects of OPEs on the morphological structure and physiological functions of the heart. It is found that these chemicals can lead to pericardial edema, abnormal looping, and thinning of atrioventricular walls in the heart, accompanied by alterations in heart rate, with toxic effects varying by the OPE type. These effects are primarily associated with the activation of endoplasmic reticulum stress response, the perturbation of cytoplasmic and intranuclear signal transduction pathways in cardiomyocytes. This paper provides a theoretical basis for further understanding of the toxic effects of OPEs and contributes to environmental protection and OPEs' ecological risk assessment.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.