ArticleWorld journal of psychiatry2023
Depression and sarcopenia-related traits: A Mendelian randomization study.
Article in World journal of psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- The bidirectional association between depression and sarcopenia: a systematic review and meta-analysis.Frontiers in public health · 2025Pooled it
- Women With Bipolar Disorder are at Increased Risk of Sarcopenia.Bipolar disorders · 2026Article
- Article
- Association of depression with sarcopenia and the impact of sleep: the first longitudinal evidence from the CHARLS.BMC public health · 2026Article
- Association between Sarcopenia-related traits and depression: an observational and Mendelian randomization analysis.European archives of psychiatry and clinical neuroscience · 2026Observational
- Handgrip strength predicts incident depression in Chinese older adults: a national prospective cohort study.BMC geriatrics · 2026Article
- Longitudinal Trajectories of Cognitive Function Among Chinese Middle-Aged and Older Adults: The Role of Sarcopenia and Depressive Symptoms.Brain sciences · 2025Article
- Physical inactivity, depressive symptoms, and progression to sarcopenia in older adults: a 4-year longitudinal study.The journal of nutrition, health & aging · 2025Article
- Effects of mindfulness meditation combined with progressive muscle relaxation on sleep disorders, anxiety, and depression in patients with sarcopenia undergoing hemodialysis.Frontiers in psychiatry · 2025Article
- Risk factors of frailty/sarcopenia in community older adults: Meta-analysis.Open medicine (Warsaw, Poland) · 2025Review
- Sarcopenia, Depressive Symptoms, and Fall Risk: Insights from a National Cohort Study in the Chinese Population.Risk management and healthcare policy · 2025Article
- Association Between Sarcopenia and Acupressure Testing in Older Adults Requiring Long-Term Care.Medicina (Kaunas, Lithuania) · 2024Article
- Associations of nutrition impact symptoms with depression in patients with advanced cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Article
- Standardizing trait selection in Mendelian randomization studies concerning sarcopenia.Journal of cachexia, sarcopenia and muscle · 2024Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundObservational studies have suggested that depression is associated with sarcopenia. However, the causal relationship between depression and sarcopenia remains unclear.
aimTo investigate the causal relationship between depression and sarcopenia.
methodsWe performed a Mendelian randomization (MR) analysis to identify the bidirectional relationship between depression and sarcopenia-related traits. Summary-level data and independent variants used as instrumental variables came from large genome-wide association studies of depression (414055 cases and 892299 controls), of appendicular lean mass (ALM, 450243 participants), and of hand grip strength (exposure: 360000 participants; outcome: 334925 participants).
resultsWe identified a negative association of depression with lower ALM [odds ratio (OR): 0.932, 95% confidence interval (95%CI): 0.889-0.979,
conclusionDepression was causally related to decreased muscle mass, and declined muscle strength might lead to a higher risk of depression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.