Evidence map›Paper›PMID 38073889›Full record

ArticleInfectious medicine2023

The role of SARS-COV-2 infection in promoting abnormal immune response and sepsis: A comparison between SARS-COV-2-related sepsis and sepsis from other causes.

Andrea Piccioni, Laura Franza, Federico Rosa, Marcello Candelli, Marcello Covino, Michela Ferrara, Gianpietro Volonnino, Giuseppe Bertozzi, Maria Vittoria Zamponi, Aniello Maiese and 3 more

Open access · goldAbstract read
In one paragraph

Article in Infectious medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Oxidative Stress in Sepsis: A Focus on Cardiac Pathology.International journal of molecular sciences · 2024
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 1 country.

Andrea PiccioniDepartment of Emergency Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, 1-00168 Rome, Italy.
Laura FranzaUniversità Cattolica del Sacro Cuore, 1-00168 Rome, Italy.
Federico RosaUniversità Cattolica del Sacro Cuore, 1-00168 Rome, Italy.
Marcello CandelliDepartment of Emergency Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, 1-00168 Rome, Italy.
Marcello CovinoDepartment of Emergency Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, 1-00168 Rome, Italy.
Michela FerraraDepartment of Anatomical, Histological, Forensic and Orthopedic Sciences, Sapienza University of Rome, 00186 Rome, Italy.
Gianpietro VolonninoDepartment of Anatomical, Histological, Forensic and Orthopedic Sciences, Sapienza University of Rome, 00186 Rome, Italy.
Giuseppe BertozziDepartment of Clinical and Experimental Medicine, Institute of Legal Medicine, University of Foggia, 71100 Foggia, Italy.
Maria Vittoria ZamponiDepartment of Anatomical, Histological, Forensic and Orthopedic Sciences, Sapienza University of Rome, 00186 Rome, Italy.
Aniello MaieseDepartment of Surgical, Medical, and Molecular Pathology and Critical Care Medicine, University of Pisa, via Roma 55, 56126 Pisa, Italy.
Gabriele SavioliEmergency Department, IRCCS Policlinico San Matteo, 27100 Pavia, Italy.
Francesco FranceschiDepartment of Emergency Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, 1-00168 Rome, Italy.
Raffaele La RussaDepartment of Clinical and Experimental Medicine, Institute of Legal Medicine, University of Foggia, 71100 Foggia, Italy.
Università Cattolica del Sacro Cuore · ITSapienza University of Rome · ITAgostino Gemelli University Polyclinic · ITUniversity of Foggia · ITUniversity of Pavia · ITUniversity of Pisa · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: COVID-19 caused by SARS-CoV-2 virus is characterized by respiratory compromise and immune system involvement, even leading to serious disorders, such as cytokine storm. Methods: We then conducted a literature review on the topic of sepsis and covid-19, and in parallel conducted an experimental study on the histological finding of patients who died from SARS-Covid 19 infection and a control group. Results: Sepsis associated with covid-19 infection has some similarities and differences from that from other causes. Conclusion: In this paper the complex interplay between the 2 disorders was discussed, focusing on the similarities and on the effect that one could have on the other. A preliminary experimental section that demonstrates the multisystemic involvement in subjects who die from SARS-CoV-2 is also proposed.

Indexed as

Cytokine stormSARS-CoV-2SARS-COV-2SepsisSeptic shock

Identifiers

PMID38073889
PMCPMC10699677
OpenAlexW4367316369

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.