Evidence map›Paper›PMID 38073467›Full record

ArticleThe Journal of infectious diseases2024

Viral Load Dynamics in Plasma and Semen When Antiretroviral Therapy Is Initiated During Early HIV-1 Infection.

Trupti Gilada, Angela K Ulrich, Yixin Wang, Javier R Lama, Ricardo Alfaro, Socorro Harb, Glenda Daza, Sarah Holte, Siavash Pasalar, Jessica Rios and 4 more

Open access · greenAbstract read
In one paragraph

Article in The Journal of infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Trial
  2. A review of bloodstream infections-pathogens, pathogenesis, diagnostic strategies, treatment methods-challenges and future aspects.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Trupti GiladaUnison Medicare and Research Center, Mumbai, India.
Angela K UlrichCenter for Infectious Disease Research and Policy, University of Minnesota, Minneapolis, Minnesota, USA.
Yixin WangVaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.
Javier R LamaAsociación Civil Impacta Salud y Educación, Lima, Peru.
Ricardo AlfaroCentro de Investigaciones Tecnológicas Biomédicas y Medioambientales, Lima, Peru.
Socorro HarbSchool of Medicine, University of Washington, Seattle, Washington, USA.
Glenda DazaSchool of Medicine, University of Washington, Seattle, Washington, USA.
Sarah HoltePublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.ORCID 0000-0001-7569-3700
Siavash PasalarVaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.ORCID 0000-0002-9683-3722
Jessica RiosPharmaceutical Product Development, Inc, Lima, Peru.
Carmela GanozaHIV Vaccine Trials Network, Lima, Peru.
Sayan DasguptaVaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.ORCID 0000-0001-5271-7247
Robert W CoombsSchool of Medicine, University of Washington, Seattle, Washington, USA.
Ann DuerrVaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.
University of Washington · USFred Hutch Cancer Center · USAsociación Civil Impacta Salud y Educación · PEUniversity of Minnesota · US

Funding

HIV Testing and Treatment to Prevent Onward HIV Transmission among High-risk MSMR01DA032106 · NIDA · FRED HUTCHINSON CANCER RESEARCH CENTER · PI DUERR, ANN C · 2011 to 2015
$6.6M
NIDA NIH HHS R01 DA032106
6 · The paper itself

Abstract

We assessed human immunodeficiency virus (HIV) load in plasma and semen during primary HIV infection using serial samples of semen and plasma during the first 24 weeks after diagnosis in untreated participants and those who started antiretroviral therapy (ART) immediately at diagnosis. In the absence of treatment, semen viral load was >1000 copies/mL in almost all specimens (83%) collected 2-10 weeks after the estimated date of HIV acquisition and remained >1000 copies/mL in 35% of untreated participants at the last observed time point. Thus, in the absence of ART, semen viral load remained at a level consistent with transmissibility throughout primary infection.

Indexed as

HIV-1HIV InfectionsHumansPlasmaRNA, ViralSemenViral LoadRNA, Viralantiretroviral therapy (ART)bloodHIVplasmasemenseminal plasmaviral load

Identifiers

PMID38073467
PMCPMC11011176
OpenAlexW4389538300

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.