Evidence map›Paper›PMID 38073338›Full record

ArticleJournal of pediatric rehabilitation medicine2023

Causes of death among people with myelomeningocele: A multi-institutional 47-year retrospective study.

Konrad M Szymanski, Cyrus M Adams, Mohammad Y Alkawaldeh, Paul F Austin, Robin M Bowman, Heidi Castillo, Jonathan Castillo, David I Chu, Carlos R Estrada, Michele Fascelli and 28 more

Open access · diamondAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pediatric rehabilitation medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. A global survey of neurosurgeons' awareness of neural tube defect prevalence, prevention strategies, and their clinical time allocation to spina bifida care.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025
    Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

38 authors at 17 institutions in 2 countries.

Konrad M SzymanskiDivision of Pediatric Urology, Riley Hospital for Children at Indiana University Health, Indianapolis, IN, USA.
Cyrus M AdamsDivision of Pediatric Urology, Riley Hospital for Children at Indiana University Health, Indianapolis, IN, USA.
Mohammad Y AlkawaldehSpina Bifida Center, Boston Children's Hospital, Boston, MA, USA.
Paul F AustinDivision of Urology, Texas Children's Hospital, Houston, TX, USA.
Robin M BowmanDivision of Neurosurgery, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA.
Heidi CastilloSection of Developmental Pediatrics, Texas Children's Hospital, Houston, TX, USA.
Jonathan CastilloSection of Developmental Pediatrics, Texas Children's Hospital, Houston, TX, USA.
David I ChuDivision of Urology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA.
Carlos R EstradaDepartment of Urology, Boston Children's Hospital, Boston, MA, USA.
Michele FascelliDepartment of Urology, Glickman Urological and Kidney Institute Cleveland Clinic Foundation, Cleveland, OH, USA.
Dominic C FrimbergerDepartment of Urology, Oklahoma University Medical Center, Oklahoma City, OK, USA.
Patricio C GargolloDivision of Urology, Mayo Clinic, Rochester, MN, USA.
Dawud G HamdanDivision of Urology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Sarah L HechtDepartment of Pediatric Urology, Children's Hospital Colorado, Aurora, CO, USA.
Betsy HopsonDepartment of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL, USA.
Douglas A HusmannDivision of Urology, Mayo Clinic, Rochester, MN, USA.
Micah A JacobsDepartment of Urology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Andrew E MacNeilyDivision of Pediatric Urology, British Columbia Children's Hospital, Vancouver, BC, Canada.
Daryl J McLeodSection of Pediatric Urology, Nationwide Children's Hospital, Columbus, OH, USA.
Peter D MetcalfeDepartment of Surgery, University of Alberta, Edmonton, Canada.
Theresa MeyerDivision of Urology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA.
Rosalia MisseriDivision of Pediatric Urology, Riley Hospital for Children at Indiana University Health, Indianapolis, IN, USA.
Joseph O'NeilDepartment of Pediatrics, Riley Hospital for Children at Indiana University Health, Indianapolis, IN, USA.
Adam J RensingDepartment of Urology, Oklahoma University Medical Center, Oklahoma City, OK, USA.
Jonathan C RouthDivision of Urologic Surgery, Duke University, Durham, NC, USA.
Kyle O RoveDepartment of Pediatric Urology, Children's Hospital Colorado, Aurora, CO, USA.
Kathleen J SawinDepartment of Nursing Research and Evidence-Based Practice, Children's Hospital of Wisconsin, Milwaukee, WI, USA.
Bruce J SchlomerDepartment of Urology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Isaac ShamblinDepartment of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL, USA.
Rebecca L SherlockSpina Bifida Center, Boston Children's Hospital, Boston, MA, USA.
Gennady SlobodovDepartment of Urology, Oklahoma University Medical Center, Oklahoma City, OK, USA.
Jennifer StoutSurgery Office of Clinical Research, Duke University, Durham, NC, USA.
Stacy T TanakaDivision of Pediatric Urology, Vanderbilt University Medical Center, Nashville, TN, USA.
Dana A WeissDivision of Urology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
John S WienerDivision of Urologic Surgery, Duke University, Durham, NC, USA.
Hadley M WoodDepartment of Urology, Glickman Urological and Kidney Institute Cleveland Clinic Foundation, Cleveland, OH, USA.
Elizabeth B YerkesDivision of Urology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA.
Jeffrey BlountDepartment of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL, USA.
Indiana University Health · USLurie Children's Hospital · USBoston Children's Hospital · USDuke University · USTexas Children's Hospital · USUniversity Medical Center · USUniversity of Alabama at Birmingham · USChildren's Hospital Colorado · USChildren's Hospital of Philadelphia · USCleveland Clinic · USMayo Clinic in Arizona · USThe University of Texas Southwestern Medical Center · USBC Children's Hospital · CAChildren's Hospital of Wisconsin · USNationwide Children's Hospital · USUniversity of Alberta · CAVanderbilt University Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study aimed to analyze organ system-based causes and non-organ system-based mechanisms of death (COD, MOD) in people with myelomeningocele (MMC), comparing urological to other COD.

methodsA retrospective review was performed of 16 institutions in Canada/United States of non-random convenience sample of people with MMC (born > = 1972) using non-parametric statistics.

resultsOf 293 deaths (89% shunted hydrocephalus), 12% occurred in infancy, 35% in childhood, and 53% in adulthood (documented COD: 74%). For 261 shunted individuals, leading COD were neurological (21%) and pulmonary (17%), and leading MOD were infections (34%, including shunt infections: 4%) and non-infectious shunt malfunctions (14%). For 32 unshunted individuals, leading COD were pulmonary (34%) and cardiovascular (13%), and leading MOD were infections (38%) and non-infectious pulmonary (16%). COD and MOD varied by shunt status and age (p < = 0.04), not ambulation or birthyear (p > = 0.16). Urology-related deaths (urosepsis, renal failure, hematuria, bladder perforation/cancer: 10%) were more likely in females (p = 0.01), independent of age, shunt, or ambulatory status (p > = 0.40). COD/MOD were independent of bladder augmentation (p = >0.11). Unexplained deaths while asleep (4%) were independent of age, shunt status, and epilepsy (p >= 0.47).

conclusionCOD varied by shunt status. Leading MOD were infectious. Urology-related deaths (10%) were independent of shunt status; 26% of COD were unknown. Life-long multidisciplinary care and accurate mortality documentation are needed.

Indexed as

HydrocephalusMeningomyeloceleCause of DeathFemaleHumansRetrospective StudiesVentriculoperitoneal Shuntcause of deathhydrocephalusmortalityMyelomeningocelespinal dysraphism

Identifiers

PMID38073338
PMCPMC10789326
OpenAlexW4389471917

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.