Evidence map›Paper›PMID 38073105›Full record

ArticleCurrent neuropharmacology2024

Redox Modulation of Meniere Disease by

Rosanna Di Paola, Rosalba Siracusa, Roberta Fusco, Marialaura Ontario, Gaetano Cammilleri, Licia Pantano, Maria Scuto, Mario Tomasello, Sestina Spanò, Angela Trovato Salinaro and 9 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current neuropharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Energy Allocation Resilience and Endocrine Integration.International journal of molecular sciences · 2026
    Review
  3. Review
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  5. Review
  6. Article
  7. Roles of Sirtuins in Hearing Protection.Pharmaceuticals (Basel, Switzerland) · 2024
    Review
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 6 institutions in 3 countries.

Rosanna Di PaolaDepartment of Veterinary Science, University of Messina, 98168, Messina, Italy.
Rosalba SiracusaDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy.
Roberta FuscoDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy.
Marialaura OntarioDepartment of Biomedical and Biotechnological Sciences; Department of Medical, Surgical Advanced Technologies "G.F. Ingrassia", University of Catania, Italy.
Gaetano CammilleriFood Department, Istituto Zooprofilattico Sperimentale della Sicilia, via Gino Marinuzzi 3 90129 Palermo, Italy.
Licia PantanoFood Department, Istituto Zooprofilattico Sperimentale della Sicilia, via Gino Marinuzzi 3 90129 Palermo, Italy.
Maria ScutoDepartment of Biomedical and Biotechnological Sciences; Department of Medical, Surgical Advanced Technologies "G.F. Ingrassia", University of Catania, Italy.
Mario TomaselloDepartment of Biomedical and Biotechnological Sciences; Department of Medical, Surgical Advanced Technologies "G.F. Ingrassia", University of Catania, Italy.
Sestina SpanòDepartment of Biomedical and Biotechnological Sciences; Department of Medical, Surgical Advanced Technologies "G.F. Ingrassia", University of Catania, Italy.
Angela Trovato SalinaroDepartment of Biomedical and Biotechnological Sciences; Department of Medical, Surgical Advanced Technologies "G.F. Ingrassia", University of Catania, Italy.
Ali S AbdelhameedDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Kingdom of Saudi Arabia.
Vincenzo FerrantelliFood Department, Istituto Zooprofilattico Sperimentale della Sicilia, via Gino Marinuzzi 3 90129 Palermo, Italy.
Antonio ArcidiaconoDepartment of Biomedical and Biotechnological Sciences; Department of Medical, Surgical Advanced Technologies "G.F. Ingrassia", University of Catania, Italy.
Tilman FritschNAM Institute, Rochusgasse 13, 5020 Salzburg, Austria.
Gabriella LupoDepartment of Biomedical and Biotechnological Sciences; Department of Medical, Surgical Advanced Technologies "G.F. Ingrassia", University of Catania, Italy.
Anna SignorileDepartment of Translational Biomedicine and Neuroscience, University of Bari, Aldo Moro, 70124, Bari, Italy.
Luigi MaiolinoDepartment of Biomedical and Biotechnological Sciences; Department of Medical, Surgical Advanced Technologies "G.F. Ingrassia", University of Catania, Italy.
Salvatore CuzzocreaDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy.
Vittorio CalabreseDepartment of Biomedical and Biotechnological Sciences; Department of Medical, Surgical Advanced Technologies "G.F. Ingrassia", University of Catania, Italy.
University of Catania · ITUniversity of Messina · ITIstituto Zooprofilattico Sperimentale Della Sicilia · ITFachhochschule Salzburg · ATKing Saud University · SAUniversity of Bari Aldo Moro · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMeniere's disease (MD) is a cochlear neurodegenerative disease. Hearing loss appears to be triggered by oxidative stress in the ganglion neurons of the inner ear.

objectiveHere, we confirm the variation of markers of oxidative stress and inflammation in patients with Meniere and hypothesize that chronic treatment with Coriolus mushroom helps in the response to oxidative stress and acts on α-synuclein and on NF-kB-mediated inflammatory processes Methods: Markers of oxidative stress and inflammation were evaluated in MD patients with or without Coriolus treatment for 3 or 6 months.

resultsMD patients had a small increase in Nrf2, HO-1, γ-GC, Hsp70, Trx and sirtuin-1, which were further increased by Coriolus treatment, especially after 6 months. Increased markers of oxidative damage, such as protein carbonyls, HNE, and ultraweak chemiluminescence, associated with a decrease in plasma GSH/GSSG ratio, were also observed in lymphocytes from MD patients. These parameters were restored to values similar to the baseline in patients treated with Coriolus for both 3 and 6 months. Furthermore, treated MD subjects showed decreased expression of α-synuclein, GFAP and Iba-1 proteins and modulation of the NF-kB pathway, which were impaired in MD patients. These changes were greatest in subjects taking supplements for 6 months.

conclusionOur study suggests MD as a model of cochlear neurodegenerative disease for the identification of potent inducers of the Nrf2-vitagene pathway, able to reduce the deleterious consequences associated with neurodegenerative damage, probably by indirectly acting on a-synuclein expression and on inflammatory processes NF-kB-mediated.

Indexed as

Meniere DiseaseNeuroprotective AgentsOxidation-ReductionOxidative StressAdultAgaricalesAgedalpha-SynucleinFemaleHumansMaleMiddle AgedNF-E2-Related Factor 2NF-kappa Balpha-SynucleinNeuroprotective AgentsNF-E2-Related Factor 2NF-kappa BCoriolus versicolorglutathioneinflammation.meniere’s diseaseneurodegenerative diseasesRedoxomicsvitagene pathway

Identifiers

PMID38073105
PMCPMC11333795
OpenAlexW4389569787

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.