Evidence map›Paper›PMID 38072979›Full record

ArticleJournal of nanobiotechnology2023

Biocompatible copper formate-based nanoparticles with strong antibacterial properties for wound healing.

Yue Zhou, Ping Sun, Yongbin Cao, Jiahao Yang, Qingzhi Wu, Jian Peng

Open access · goldAbstract read
In one paragraph

Article in Journal of nanobiotechnology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 24 citations in OpenAlex.

  1. Nanoparticle-based approaches for bacterial detection and therapy.Applied microbiology and biotechnology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yue ZhouState Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan, 430070, China.
Ping SunState Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan, 430070, China.
Yongbin CaoState Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan, 430070, China.
Jiahao YangState Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan, 430070, China.
Qingzhi WuState Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan, 430070, China. wuqzh@whut.edu.cn.
Jian PengState Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan, 430070, China. jianpeng@whut.edu.cn.
State Key Laboratory of Advanced Technology For Materials Synthesis and ProcessingWuhan University of Technology · CN

Funding

National Natural Science Foundation of China No. 21905237 and 82302275the 7th Yong elite scientist sponsorship program by CAST No. YESS20210191the Fundamental Research Funds for the Central Universities WUT: 2022IVA160 and 2022IVA089The Young Top-notch Talent Cultivation Program of Hubei Province No. 40129014
6 · The paper itself

Abstract

Copper-based antibacterial materials have emerged as a potential alternative for combating bacterial infections, which continue to pose significant health risks. Nevertheless, the use of copper-based nanoparticles as antibacterial agents has faced challenges due to their toxicity towards cells and tissues. To overcome this obstacle, we propose a new approach using a contact-active copper-based nanoparticles called polydopamine (PDA)-coated copper-amine (Cuf-TMB@PDA). The positively charged surface of Cuf-TMB@PDA enables efficient targeting of negatively charged bacteria, allowing controlled release of Cu(II) into the bacterial cell membrane. Moreover, Cuf-TMB@PDA exhibits similar ·OH signals as Cuf-TMB suspensions in previous work. In cytotoxicity assays conducted over 72 h, Cuf-TMB@PDA demonstrated an efficacy of 98.56%, while releasing lower levels of Cu(II) that were less harmful to cells, resulting in enhanced antimicrobial effects. These antimicrobial properties are attributed to the synergistic effects of charge-contact activity of PDA, controlled release of Cu(II), and free radicals. Subsequent in vivo experiments confirmed the strong antimicrobial potency of Cuf-TMB@PDA and its ability to promote wound healing.

Indexed as

CopperNanoparticlesAnti-Bacterial AgentsDelayed-Action PreparationsFormatesWound HealingAnti-Bacterial AgentsCopperDelayed-Action PreparationsFormatesAntibacterialBioactiveCuf-TMB@PDA·OH radicalWound healing

Identifiers

PMID38072979
PMCPMC10710715
OpenAlexW4389522318

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.