Evidence map›Paper›PMID 38072936›Full record

ArticleJournal of nanobiotechnology2023

Temporally and spatially resolved molecular profiling in fingerprint analysis using indium vanadate nanosheets-assisted laser desorption ionization mass spectrometry.

Yanli Zhu, Jikai Wang, Chengxiao Fu, Shuangquan Liu, Pragati Awasthi, Pengfei Zeng, Danjun Chen, Yiyang Sun, Ziyi Mo, Hailing Liu

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Yanli ZhuSchool of Resources and Environment, Hunan University of Technology and Business, Changsha, Hunan, 410205, P. R. China.
Jikai WangHunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Institute of Pharmacy & Pharmacology, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, P. R. China. jkwang@hnu.edu.cn.
Chengxiao FuThe First Affiliated Hospital, Department of Clinical Laboratory, Department of Pharmacy, Hengyang Clinical Pharmacology Research Center, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, P. R. China.
Shuangquan LiuThe First Affiliated Hospital, Department of Clinical Laboratory, Department of Pharmacy, Hengyang Clinical Pharmacology Research Center, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, P. R. China.
Pragati AwasthiState Key Laboratory of Silicon Materials & School of Materials Science and Engineering, Zhejiang University, Hangzhou, Zhejiang, 310058, P. R. China.
Pengfei ZengHunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Institute of Pharmacy & Pharmacology, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, P. R. China.
Danjun ChenThe First Affiliated Hospital, Department of Clinical Laboratory, Department of Pharmacy, Hengyang Clinical Pharmacology Research Center, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, P. R. China.
Yiyang SunHunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Institute of Pharmacy & Pharmacology, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, P. R. China.
Ziyi MoHunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Institute of Pharmacy & Pharmacology, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, P. R. China.
Hailing LiuDepartment of Respiratory and Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, P. R. China.
University of South China · CNHunan University of Technology · CNWuhan University · CNZhejiang University · CN

Funding

Doctoral Scientific Research Foundation of University of South China 200XQD042Macao Young Scholars Program AM2022020Medical Technology Innovation Guidance Project of Hunan Province Science and Technology Department 2020SK51805Natural Science Foundation of Hunan Province 2023JJ40220Natural Science Foundation of Hunan Province, China 2021JJ40452Natural Science Foundation of Hunan Province, China 2021JJ80072Natural Science Foundation of Hunan Province, China 2023JJ60494Scientific Research Project of Hunan Provincial Education Department 22B0455Scientific Research Project of Hunan Provincial Health Commission 202112062218
6 · The paper itself

Abstract

This study presents the first-ever synthesis of samarium-doped indium vanadate nanosheets (IVONSs:Sm) via microemulsion-mediated solvothermal method. The nanosheets were subsequently utilized as a nano-matrix in laser desorption/ionization mass spectrometry (LDI-MS). It was discovered that the as-synthesized IVONSs:Sm possessed the following advantages: improved mass spectrometry signal, minimal matrix-related background, and exceptional stability in negative-ion mode. These qualities overcame the limitations of conventional matrices and enabled the sensitive detection of small biomolecules such as fatty acids. The negative-ion LDI mechanism of IVONSs:Sm was examined through the implementation of density functional theory simulation. Using IVONSs:Sm-assisted LDI-MS, fingerprint recognitions based on morphology and chemical profiles of endogenous/exogenous compounds were also achieved. Notably, crucial characteristics such as the age of an individual's fingerprints and their physical state could be assessed through the longitudinal monitoring of particular biomolecules (e.g., ascorbic acid, fatty acid) or the specific biomarker bilirubin glucuronide. Critical information pertinent to the identification of an individual would thus be facilitated by the analysis of the compounds underlying the fingerprint patterns.

Indexed as

IndiumVanadatesFatty AcidsLasersSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationFatty AcidsIndiumVanadatesChemical mappingFingerprint analysisIndium vanadate nanosheetsIonization mechanismMass spectrometry imaging

Identifiers

PMID38072936
PMCPMC10710729
OpenAlexW4389521952

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.