ArticleScientific reports2023
Combination strategy for prognostication in patients undergoing post-resuscitation care after cardiac arrest.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- cEEG and rEEG detection rates of prognostic indicators in cardiac arrest patients: a systematic review and diagnostic meta-analysis.Frontiers in neurologyPooled it
- Comprehensive pre- and in-hospital near-infrared-spectroscopy (NIRS) monitoring after return of spontaneous circulation predicts neurological outcome following out-of-hospital cardiac arrest: a prospective observational study and literature review.Frontiers in medicine · 2025Article
- Quantitative analysis of apparent diffusion coefficients to predict neurological prognosis in cardiac arrest survivors: an observational derivation and internal-external validation study.Critical care (London, England) · 2024Observational
- Neuroprognostication after cardiac arrest: Updated insights from the 2025 ERC-ESICM guidelines.Journal of anaesthesiology, clinical pharmacologyArticle
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Authors and funding
10 authors.
Funding
Abstract
This study investigated the prognostic performance of combination strategies using a multimodal approach in patients treated after cardiac arrest. Prospectively collected registry data were used for this retrospective analysis. Poor outcome was defined as a cerebral performance category of 3-5 at 6 months. Predictors of poor outcome were absence of ocular reflexes (PR/CR) without confounding factors, a highly malignant pattern on the most recent electroencephalography, defined as suppressed background with or without periodic discharges and burst-suppression, high neuron-specific enolase (NSE) after 48 h, and diffuse injury on imaging studies (computed tomography or diffusion-weighted imaging [DWI]) at 72-96 h. The prognostic performances for poor outcomes were analyzed for sensitivity and specificity. A total of 130 patients were included in the analysis. Of these, 68 (52.3%) patients had poor outcomes. The best prognostic performance was observed with the combination of absent PR/CR, high NSE, and diffuse injury on DWI [91.2%, 95% confidence interval (CI) 80.7-97.1], whereas the combination strategy of all available predictors did not improve prognostic performance (87.8%, 95% CI 73.8-95.9). Combining three of the predictors may improve prognostic performance and be more efficient than adding all tests indiscriminately, given limited medical resources.
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