Evidence map›Paper›PMID 38072152›Full record

ArticleThe Journal of nutrition2024

Prognostic Performance of Hematological and Serum Iron and Metabolite Indices for Detection of Early Iron Deficiency Induced Metabolic Brain Dysfunction in Infant Rhesus Monkeys.

Brian J Sandri, Jonathan Kim, Gabriele R Lubach, Eric F Lock, Kathleen Ennis-Czerniak, Pamela J Kling, Michael K Georgieff, Christopher L Coe, Raghavendra B Rao

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.7field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Brian J SandriDivision of Neonatology, Department of Pediatrics, University of Minnesota, Minneapolis, MN, United States; Masonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN, United States.
Jonathan KimDivision of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, United States.
Gabriele R LubachHarlow Center for Biological Psychology, University of Wisconsin, Madison, WI, United States.
Eric F LockDivision of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, United States.
Kathleen Ennis-CzerniakDivision of Neonatology, Department of Pediatrics, University of Minnesota, Minneapolis, MN, United States.
Pamela J KlingDivision of Neonatology, Department of Pediatrics, University of Wisconsin, Madison, WI, United States.
Michael K GeorgieffDivision of Neonatology, Department of Pediatrics, University of Minnesota, Minneapolis, MN, United States; Masonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN, United States.
Christopher L CoeHarlow Center for Biological Psychology, University of Wisconsin, Madison, WI, United States.
Raghavendra B RaoDivision of Neonatology, Department of Pediatrics, University of Minnesota, Minneapolis, MN, United States; Masonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN, United States. Electronic address: raghurao@umn.edu.
University of Minnesota · USUniversity of Wisconsin–Madison · US

Funding

STATISTICAL COREP01HD039386 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LOZOFF, BETSY · 2001 to 2011
$14.0M
Detection and Correction of Iron Deficiency Induced Abnormal Brain MetabolismR01HD089989 · NICHD · UNIVERSITY OF MINNESOTA · PI COE, CHRISTOPHER L, GEORGIEFF, MICHAEL K. · 2017 to 2021
$2.7M
Novel Medical Food for Treating Infant Anemia and Iron Deficiency in the CNSR01HD080201 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI COE, CHRISTOPHER L · 2014 to 2018
$2.1M
Gestational Stress and Impaired Iron Homeostasis in the Young InfantR01HD057064 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI COE, CHRISTOPHER L · 2009 to 2013
$1.6M
Identifying Biomarkers from Multi-source, Multi-way DataR01GM130622 · NIGMS · UNIVERSITY OF MINNESOTA · PI LOCK, ERIC F · 2019 to 2023
$1.5M
NICHD NIH HHS P01 HD039386NICHD NIH HHS R01 HD057064NICHD NIH HHS R01 HD080201NICHD NIH HHS R01 HD089989NIGMS NIH HHS R01 GM130622
6 · The paper itself

Abstract

backgroundThe current pediatric practice of monitoring for infantile iron deficiency (ID) via hemoglobin (Hgb) screening at one y of age does not identify preanemic ID nor protect against later neurocognitive deficits.

objectivesTo identify biomarkers of iron-related metabolic alterations in the serum and brain and determine the sensitivity of conventional iron and heme indices for predicting risk of brain metabolic dysfunction using a nonhuman primate model of infantile ID.

methodsSimultaneous serum iron and RBC indices, and serum and cerebrospinal fluid (CSF) metabolomic profiles were determined in 20 rhesus infants, comparing iron sufficient (IS; N = 10) and ID (N = 10) infants at 2 and 4 mo of age.

resultsReticulocyte hemoglobin (RET-He) was lower at 2 wk in the ID group. Significant IS compared with ID differences in serum iron indices were present at 2 mo, but Hgb and RBC indices differed only at 4 mo (P < 0.05). Serum and CSF metabolomic profiles of the ID and IS groups differed at 2 and 4 mo (P < 0.05). Key metabolites, including homostachydrine and stachydrine (4-5-fold lower at 4 mo in ID group, P < 0.05), were altered in both serum and CSF. Iron indices and RET-He at 2 mo, but not Hgb or other RBC indices, were correlated with altered CSF metabolic profile at 4 mo and had comparable predictive accuracy (area under the receiver operating characteristic curve scores, 0.75-0.80).

conclusionsPreanemic ID at 2 mo was associated with metabolic alterations in serum and CSF in infant monkeys. Among the RBC indices, only RET-He predicted the future risk of abnormal CSF metabolic profile with a predictive accuracy comparable to serum iron indices. The concordance of homostachydrine and stachydrine changes in serum and CSF indicates their potential use as early biomarkers of brain metabolic dysfunction in infantile ID.

Indexed as

Anemia, Iron-DeficiencyBrain DiseasesIron DeficienciesAnimalsBiomarkersBrainChildHemoglobinsHumansInfantIronMacaca mulattaPrognosisBiomarkersHemoglobinsIronbiomarkershemoglobinhomostachydrineinfantile anemiaironiron deficiencymetabolomicsreticulocyte hemoglobinstachydrine

Identifiers

PMID38072152
PMCPMC10942850
OpenAlexW4389513502

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.