Evidence map›Paper›PMID 38071695›Full record

ArticleMolecular biology reports2023

Polymorphisms and expressions of ADSL, MC4R and CAPN1 genes and their effects on economic traits in Egyptian chicken breeds.

Dalia M Aboelhassan, Hassan R Darwish, Hayam Mansour, Hesham Abozaid, Inas S Ghaly, Hasnaa A Radwan, Eman R Hassan, Ibrahim M Farag

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Article in Molecular biology reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Dalia M AboelhassanDepartment of Cell Biology, Biotechnology Research Institute, National Research Centre, 33st El Bohouth, Dokki, Giza, 12622, Egypt. dalia_hemdan@yahoo.com.ORCID http://orcid.org/0000-0003-4340-1157
Hassan R DarwishDepartment of Cell Biology, Biotechnology Research Institute, National Research Centre, 33st El Bohouth, Dokki, Giza, 12622, Egypt.ORCID http://orcid.org/0000-0001-9141-2278
Hayam MansourDepartment of Cell Biology, Biotechnology Research Institute, National Research Centre, 33st El Bohouth, Dokki, Giza, 12622, Egypt.ORCID http://orcid.org/0000-0003-2934-4125
Hesham AbozaidDepartment of Animal Production, Agricultural and Biology Institute, National Research Centre, Giza, 12622, Egypt.ORCID http://orcid.org/0000-0002-8694-6010
Inas S GhalyDepartment of Cell Biology, Biotechnology Research Institute, National Research Centre, 33st El Bohouth, Dokki, Giza, 12622, Egypt.ORCID http://orcid.org/0000-0003-3425-7341
Hasnaa A RadwanDepartment of Cell Biology, Biotechnology Research Institute, National Research Centre, 33st El Bohouth, Dokki, Giza, 12622, Egypt.ORCID http://orcid.org/0000-0003-2192-7705
Eman R HassanDepartment of Poultry Disease, Veterinary Research Institute, National Research Centre, Giza, 12622, Egypt.ORCID http://orcid.org/0000-0002-5918-2254
Ibrahim M FaragDepartment of Cell Biology, Biotechnology Research Institute, National Research Centre, 33st El Bohouth, Dokki, Giza, 12622, Egypt.ORCID http://orcid.org/0000-0002-7918-9437

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent years, strategic plans for poultry production have emphasized quantitative traits, particularly body weight and carcass traits (meat yield), in response to overpopulation challenges. Candidate genes such as adenylosuccinate lyase (ADSL), melanocortin-4-receptor (MC4R), and calpain 1 (CAPN1) have played vital roles in this context due to their associations with muscle growth and body composition. This study aims to investigate the influence of polymorphisms and gene expressions of the aforementioned genes on body weight (BW), growth rate (GR), breast weight (BrW), and thigh weight (TW) across four distinct chicken breeds: Fayoumi, Matrouh, Mamourah, and Leghorn. The use of PCR-SSCP analysis revealed genetic polymorphisms through the identification of various patterns (genotypes) within the three examined genes. The ADSL, MC4R, and CAPN1 genes exhibited five, three, and two different genotypes, respectively. These polymorphisms displayed promising connections with enhancing economically significant production traits, particularly BW, BrW and TW. Furthermore, gene expression analyses were conducted on breast and thigh tissues obtained from the chicken breeds at 60 days of age, where ADSL and MC4R exhibited a noteworthy up-regulation in Fayoumi and Matrouh breeds, and down-regulation in Mamourah and Leghorn. In contrast, CAPN1 expression decreased across most breeds with a slight increase noted in Fayoumi breed. In conclusion, this investigation underscores the substantial impact of ADSL, MC4R, and CAPN1 genes on economically important production traits within Egyptian domestic chicken breeds. Consequently, these genes emerge as significant molecular markers, holding potential utility in avian selection and breeding programs aimed at enhancing productive performance.

Indexed as

Adenylosuccinate LyaseChickensAnimalsBody WeightEgyptGenotypeMeatPolymorphism, Single NucleotideAdenylosuccinate LyaseADSL, MC4R and CAPN1 genesChicken breedsEconomic traitsPCR-SSCPReal-time PCR

Identifiers

PMID38071695
PMCPMC10710965

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.