Evidence map›Paper›PMID 38071303›Full record

ArticleNature communications2023

The distinct translational landscapes of gram-negative Salmonella and gram-positive Listeria.

Owain J Bryant, Filip Lastovka, Jessica Powell, Betty Y-W Chung

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

Owain J Bryant *Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK.
Filip Lastovka *Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK.ORCID 0000-0002-5459-7418
Jessica PowellDepartment of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK.
Betty Y-W ChungDepartment of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK. bcy23@cam.ac.uk.ORCID 0000-0003-4384-285X
University of Cambridge · GB

Funding

RCUK | Biotechnology and Biological Sciences Research Council (BBSRC) BB/V006096/1RCUK | Biotechnology and Biological Sciences Research Council (BBSRC) BB/V017780/1RCUK | Biotechnology and Biological Sciences Research Council (BBSRC) BB/X001261/1RCUK | Medical Research Council (MRC) MR/R021821/1Royal Society RGS\R2\192222
6 · The paper itself

Abstract

Translational control in pathogenic bacteria is fundamental to gene expression and affects virulence and other infection phenotypes. We used an enhanced ribosome profiling protocol coupled with parallel transcriptomics to capture accurately the global translatome of two evolutionarily distant pathogenic bacteria-the Gram-negative bacterium Salmonella and the Gram-positive bacterium Listeria. We find that the two bacteria use different mechanisms to translationally regulate protein synthesis. In Salmonella, in addition to the expected correlation between translational efficiency and cis-regulatory features such as Shine-Dalgarno (SD) strength and RNA secondary structure around the initiation codon, our data reveal an effect of the 2

Indexed as

ListeriaProtein BiosynthesisBacteriaCodonCodon, InitiatorEscherichia coliPeptide Chain Initiation, TranslationalRNA, MessengerCodonCodon, InitiatorRNA, Messenger

Identifiers

PMID38071303
PMCPMC10710512
OpenAlexW4389506196

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.