Evidence map›Paper›PMID 38071152›Full record

ArticleBritish journal of anaesthesia2024

Effect of prolonged sedation with dexmedetomidine, midazolam, propofol, and sevoflurane on sleep homeostasis in rats.

Brian H Silverstein, Anjum Parkar, Trent Groenhout, Zuzanna Fracz, Anna M Fryzel, Christopher W Fields, Amanda Nelson, Tiecheng Liu, Giancarlo Vanini, George A Mashour and 1 more

Erratum issuedOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of anaesthesia, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Brian H SilversteinDepartment of Anesthesiology, University of Michigan, Ann Arbor, MI, USA; Center for Consciousness Science, University of Michigan, Ann Arbor, MI, USA.
Anjum ParkarDepartment of Anesthesiology, University of Michigan, Ann Arbor, MI, USA.
Trent GroenhoutDepartment of Anesthesiology, University of Michigan, Ann Arbor, MI, USA.
Zuzanna FraczDepartment of Anesthesiology, University of Michigan, Ann Arbor, MI, USA.
Anna M FryzelDepartment of Anesthesiology, University of Michigan, Ann Arbor, MI, USA.
Christopher W FieldsDepartment of Anesthesiology, University of Michigan, Ann Arbor, MI, USA.
Amanda NelsonDepartment of Anesthesiology, University of Michigan, Ann Arbor, MI, USA.
Tiecheng LiuDepartment of Anesthesiology, University of Michigan, Ann Arbor, MI, USA.
Giancarlo VaniniDepartment of Anesthesiology, University of Michigan, Ann Arbor, MI, USA; Center for Consciousness Science, University of Michigan, Ann Arbor, MI, USA; Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI, USA.
George A MashourDepartment of Anesthesiology, University of Michigan, Ann Arbor, MI, USA; Center for Consciousness Science, University of Michigan, Ann Arbor, MI, USA; Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI, USA.
Dinesh PalDepartment of Anesthesiology, University of Michigan, Ann Arbor, MI, USA; Center for Consciousness Science, University of Michigan, Ann Arbor, MI, USA; Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI, USA; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA. Electronic address: dineshp@med.umich.edu.
University of Michigan · US

Funding

Neurochemical mechanisms of sedative effects on sleep homeostasisR01GM121919 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PAL, DINESH · 2018 to 2022
$1.6M
NIGMS NIH HHS R01 GM121919
6 · The paper itself

Abstract

backgroundSleep disruption is a common occurrence during medical care and is detrimental to patient recovery. Long-term sedation in the critical care setting is a modifiable factor that affects sleep, but the impact of different sedative-hypnotics on sleep homeostasis is not clear.

methodsWe conducted a systematic comparison of the effects of prolonged sedation (8 h) with i.v. and inhalational agents on sleep homeostasis. Adult Sprague-Dawley rats (n=10) received dexmedetomidine or midazolam on separate days. Another group (n=9) received propofol or sevoflurane on separate days. A third group (n=12) received coadministration of dexmedetomidine and sevoflurane. Wakefulness (wake), slow-wave sleep (SWS), and rapid eye movement (REM) sleep were quantified during the 48-h post-sedation period, during which we also assessed wake-associated neural dynamics using two electroencephalographic measures: theta-high gamma phase-amplitude coupling and high gamma weighted phase-lag index.

resultsDexmedetomidine-, midazolam-, or propofol-induced sedation increased wake and decreased SWS and REM sleep (P<0.0001) during the 48-h post-sedation period. Sevoflurane produced no change in SWS, decreased wake for 3 h, and increased REM sleep for 6 h (P<0.02) post-sedation. Coadministration of dexmedetomidine and sevoflurane induced no change in wake (P>0.05), increased SWS for 3 h, and decreased REM sleep for 9 h (P<0.02) post-sedation. Dexmedetomidine, midazolam, and coadministration of dexmedetomidine with sevoflurane reduced wake-associated phase-amplitude coupling (P≤0.01). All sedatives except sevoflurane decreased wake-associated high gamma weighted phase-lag index (P<0.01).

conclusionsIn contrast to i.v. drugs, prolonged sevoflurane sedation produced minimal changes in sleep homeostasis and neural dynamics. Further studies are warranted to assess inhalational agents for long-term sedation and sleep homeostasis.

Indexed as

DexmedetomidineElectroencephalographyHomeostasisHypnotics and SedativesMidazolamPropofolRats, Sprague-DawleySevofluraneSleepAnesthetics, InhalationAnimalsMaleRatsWakefulnessAnesthetics, InhalationDexmedetomidineHypnotics and SedativesMidazolamPropofolSevofluranedexmedetomidinefunctional connectivityphase-amplitude couplingpropofolratsedationsevofluranesleep homeostasis

Identifiers

PMID38071152
PMCPMC11541083
OpenAlexW4389473420

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.