Evidence map›Paper›PMID 38070921›Full record

Trial reportBMJ open2023

INvestigational Study Into Transplantation of the Uterus (INSITU): a cross-sectional survey among women with uterine factor infertility in the UK assessing background, motivations and suitability.

Benjamin P Jones, Saaliha Vali, Lorraine S Kasaven, Ifigenia Mantrali, Srdjan Saso, Timothy Bracewell-Milnes, James Nicopoullos, Meen-Yau Thum, Cesar Diaz-Garcia, Isabel Quiroga and 2 more

Registry-linked trialAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMJ open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02388802 (The First Human Clinical Trial of Uterine Transplantation in the United Kingdom), which is not on this map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02388802 naunknown statusnot on this map

The First Human Clinical Trial of Uterine Transplantation in the United Kingdom

TypeinterventionalSponsorWomb Transplant UKRan2017 to 2020Enrolled10ConditionsInfertilityArmsOocyte retrieval and freezing, Deceased Donor Allograft Excision, Uterine Transplantation, Immunosuppressive Agents, In-vitro fertilisation
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Past, Present, and Future: A Review of Uterus Transplant.Transplant international : official journal of the European Society for Organ Transplantation · 2025
    Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Benjamin P JonesLister Fertility Clinic, The Lister Hospital, London, UK benjamin.jones@nhs.net.ORCID 0000-0002-0391-0443
Saaliha ValiImperial College Healthcare NHS Trust, London, UK.ORCID 0000-0002-7289-0407
Lorraine S KasavenDepartment of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
Ifigenia MantraliImperial College Healthcare NHS Trust, London, UK.
Srdjan SasoImperial College Healthcare NHS Trust, London, UK.
Timothy Bracewell-MilnesLister Fertility Clinic, The Lister Hospital, London, UK.
James NicopoullosLister Fertility Clinic, The Lister Hospital, London, UK.
Meen-Yau ThumLister Fertility Clinic, The Lister Hospital, London, UK.
Cesar Diaz-GarciaIVI London, IVIRMA Global, London, UK.
Isabel QuirogaOxford University Hospitals NHS Trust, Oxford, UK.
Joseph YazbekImperial College Healthcare NHS Trust, London, UK.
James Richard SmithDepartment of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

importanceThe study summarises the selection prescreen criteria currently used in the UK for a uterus transplant and highlights the number of women who are suitable to proceed.

objectivesTo assess the demographics, motivations, reasons and suitability among women with absolute uterine factor infertility (AUFI) to undergo uterine transplantation (UTx).

designA cross-sectional survey.

settingAn electronic questionnaire was sent via email to women with AUFI who had previously been referred to the UTx research team or approached the Womb Transplant UK Charity. The questions assessed suitability to undergo UTx based on demographic information, perceptions to adoption and surrogacy and reasons why UTx was preferable. Responses were assessed against the study selection criteria.

participantsWomen with AUFI.

results210 women completed the questionnaire. The most common aetiology of AUFI in our cohort was Mayer-Rokitansky-Küster-Hauser (68%; n=143) whereas 29% (n=62) had previously undergone hysterectomy. 63% (n=132) of the cohort had previously considered adoption, 5% (n=11) had attempted it and 2 (1%) had successfully adopted. The most common reason cited to undergo UTx over adoption was to experience gestation (n=63; 53%), while 37% (n=44) wanted a biologically related child. 76% (n=160) of participants had previously considered surrogacy, 22 (10%) had attempted it and 2 (1%) had successfully become mothers using a surrogate. The most common reason to undergo UTx over surrogacy was to experience gestation (n=77; 54%). 15% (n=21) were concerned about the legal implications, 14% (n=20) identified the financial cost as a barrier and 8% (n=12) could not consider it due to religious reasons. On adhering to the selection criteria, 65 (31%) women were suitable to proceed with the trial.

conclusionThe study demonstrates that implementing commonly used selection criteria for a UTx led to an attrition rate of more than two-thirds of women who requested to initially undergo the process. As more studies present outcomes following UTx, critical assessment of the selection criteria currently used is warranted to ensure potential recipients are not being unnecessarily excluded. TRIAL REGISTRATION NUMBER: NCT02388802.

Indexed as

Infertility, FemaleUterusCross-Sectional StudiesFemaleHumansMotivationUnited KingdomGYNAECOLOGYReproductive medicineTransplant surgery

Identifiers

PMID38070921
PMCPMC10728960

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.