Evidence map›Paper›PMID 38070852›Full record

Trial reportEnvironmental research2024

Indoor particulate matter concentrations and air cleaner intervention association with biomarkers in former smokers with COPD.

Ashraf Fawzy, Han Woo, Sarath Raju, Daniel C Belz, Nirupama Putcha, Marlene S Williams, Meredith C McCormack, Kirsten Kohler, Nadia N Hansel

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Environmental research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Health Benefits of Air Purification: A Systematic Review.Environment & health (Washington, D.C.) · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Ashraf FawzyDivision of Pulmonary and Critical Care, Johns Hopkins University, Baltimore, MD, USA. Electronic address: afawzy1@jhmi.edu.
Han WooDivision of Pulmonary and Critical Care, Johns Hopkins University, Baltimore, MD, USA.
Sarath RajuDivision of Pulmonary and Critical Care, Johns Hopkins University, Baltimore, MD, USA.
Daniel C BelzDivision of Pulmonary and Critical Care, Johns Hopkins University, Baltimore, MD, USA.
Nirupama PutchaDivision of Pulmonary and Critical Care, Johns Hopkins University, Baltimore, MD, USA.
Marlene S WilliamsDivision of Cardiology, Johns Hopkins University, Baltimore, MD, USA.
Meredith C McCormackDivision of Pulmonary and Critical Care, Johns Hopkins University, Baltimore, MD, USA; Department of Environmental Health Sciences and Engineering, Johns Hopkins University, Baltimore, MD, USA.
Kirsten KohlerDepartment of Environmental Health Sciences and Engineering, Johns Hopkins University, Baltimore, MD, USA.
Nadia N HanselDivision of Pulmonary and Critical Care, Johns Hopkins University, Baltimore, MD, USA; Department of Environmental Health Sciences and Engineering, Johns Hopkins University, Baltimore, MD, USA.
Johns Hopkins University · US

Funding

MULTIDISCIPLINARY TRAINING PROGRAM IN LUNG DISEASEST32HL007534 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Nadia N Hansel, Larissa A. Shimoda · 1985 to 2026
$28.3M
Clinical trial of air cleaners to improve indoor air quality and COPD healthR01ES022607 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI HANSEL, NADIA N · 2013 to 2017
$3.4M
The association of allergic disease with clinical outcomes in COPD.K23HL123594 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI PUTCHA, NIRUPAMA · 2015 to 2019
$1.0M
Platelet Activation Pathways and Respiratory Morbidity in COPDK23HL151758 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI FAWZY, ASHRAF · 2021 to 2025
$986k
Clean Air- Heart: Clinical trial of an air purifier intervention to reduce indoor particulate matter and improve cardiovascular outcomes in COPDR21ES025840 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI MCCORMACK, MEREDITH C · 2015 to 2016
$446k
The role of platelet activation and particulate matter exposure in COPD morbidityF32ES028576 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI FAWZY, ASHRAF · 2017 to 2018
$135k
NHLBI NIH HHS K23 HL123594NHLBI NIH HHS K23 HL151758NHLBI NIH HHS T32 HL007534NIEHS NIH HHS F32 ES028576NIEHS NIH HHS R01 ES022607NIEHS NIH HHS R21 ES025840
6 · The paper itself

Abstract

backgroundIndoor pollutants have been associated with worse clinical outcomes in chronic obstructive pulmonary disease (COPD). Elevated biomarkers are associated with ambient pollution exposure, however the association with indoor pollution remains unclear.

methodsFormer smokers with spirometry-confirmed COPD were randomized to portable air cleaner or placebo. Indoor particulate matter (PM

resultsFifty-eight participants were randomized to each group. Finer PM was more strongly associated with higher IL-8 (mean difference per doubling: UFP 13.9% [p = 0.02], PM DISCUSSION: Among former smokers with COPD, elevated levels of indoor air pollutants, particularly ultrafine particles (PM

Indexed as

Air PollutantsAir PollutionAir Pollution, IndoorPulmonary Disease, Chronic ObstructiveBiomarkersCD40 LigandEnvironmental ExposureHumansInflammationInterferon-gammaInterleukin-8Particulate MatterP-SelectinSmokersThiobarbituric Acid Reactive SubstancesAir PollutantsBiomarkersCD40 LigandInterferon-gammaInterleukin-8Particulate MatterP-SelectinThiobarbituric Acid Reactive SubstancesChronic obstructive pulmonary diseaseIndoor air pollutionInflammationOxidative stressPlatelet activationUltrafine particles

Identifiers

PMID38070852
PMCPMC10872275
OpenAlexW4389430572

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.