Evidence map›Paper›PMID 38070749›Full record

ArticleJournal of affective disorders2024

Prenatal mood and anxiety disorders and associated cytokine changes.

Roberta A Mancuso, Kharah M Ross, Eynav Accortt, Mary Coussons-Read, Michele L Okun, Jessica Irwin, Judith Carroll, Calvin J Hobel, Christine Dunkel Schetter

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of affective disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Biomarkers of reproductive psychiatric disorders.The British journal of psychiatry : the journal of mental science · 2025
    Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 2 countries.

Roberta A MancusoDepartment of Psychology and Neuroscience, Regis University, Denver, CO, USA. Electronic address: rmancuso@regis.edu.
Kharah M RossCentre for Social Sciences, Athabasca University, Athabasca, AB, Canada.
Eynav AccorttReproductive Psychology Program, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Mary Coussons-ReadDepartment of Psychology, University of Colorado - Colorado Springs, Colorado Springs, CO, USA.
Michele L OkunSleep and Biobehavioral Health Research Laboratory, University of Colorado - Colorado Springs, Colorado Springs, CO, USA.
Jessica IrwinDepartment of Psychology, University of La Verne, La Verne, CA, USA.
Judith CarrollCousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Calvin J HobelDepartment of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Christine Dunkel SchetterDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, USA.
Cedars-Sinai Medical Center · USUniversity of California, Los Angeles · USUniversity of Colorado Colorado Springs · USAthabasca University · CARegis University · USUniversity of La Verne · US

Funding

CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR025780 · NCRR · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2008 to 2011
$61.3M
PREVENTION RESEARCH TRAINING:URBAN CHILDREN'S MENT HLTHT32MH015750 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHRISTINE DUNKEL SCHETTER · 1985 to 2026
$6.2M
Mechanisms & Effects of Prenatal Maternal Affect on Pregnancy & Infant DevelopmentR01HD073491 · NICHD · UNIVERSITY OF COLORADO · PI COUSSONS-READ, MARY E, DUNKEL SCHETTER, CHRISTINE · 2013 to 2017
$3.1M
NCRR NIH HHS UL1 RR025780NICHD NIH HHS R01 HD073491NIMH NIH HHS T32 MH015750
6 · The paper itself

Abstract

backgroundWe examined whether women with prenatal mood and anxiety disorders would exhibit differential pro- and anti-inflammatory marker trajectories during the prenatal and postpartum periods compared to women without these disorders.

methodsApproximately 179 pregnant women participated in a longitudinal study conducted in two urban areas. Blood samples for inflammatory markers were collected at six study visits. The Structured Clinical Interview for the DSM-IV (SCID) was administered to participants scoring above cutoffs on anxiety and depression. Pregnant women with SCID Axis I diagnoses of mood and/or anxiety disorders were compared to other participants on inflammatory markers. Multilevel modeling tested associations between SCID diagnoses and within-person interleukin (IL)6 and IL10 trajectories.

resultsPrenatal SCID diagnoses were associated with linear, quadratic and cubic change in IL6 from prenatal to postpartum timepoints. Women with a prenatal SCID diagnosis had steeper decreases and increases in IL6 during prenatal and postpartum periods. SCID diagnoses were associated with lower IL10 in mid-pregnancy to postpartum (b = -0.078, SE = 0.019; p = .015). LIMITATIONS: Future studies would benefit from a larger sample size and a larger number of participants with SCID diagnoses. Future research should also examine whether different prenatal Axis 1 diagnoses are associated with different patterns of immune response in pregnancy.

conclusionsPregnant women with prenatal mood and anxiety disorders had greater fluctuations in IL6 across prenatal and postpartum periods and lower IL10 through pregnancy and postpartum. They may have different proinflammatory states that remain after birth without a reciprocal anti-inflammatory response.

Indexed as

Depression, PostpartumPregnancy ComplicationsAnti-Inflammatory AgentsAnxietyAnxiety DisordersCytokinesDepressionFemaleHumansInterleukin-10Interleukin-6Longitudinal StudiesMood DisordersPostpartum PeriodPregnancyAnti-Inflammatory AgentsCytokinesInterleukin-10Interleukin-6Anxiety disorderIL-10IL-6Mood disorderPregnancySCID

Identifiers

PMID38070749
PMCPMC11375962
OpenAlexW4389454379

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.