Evidence map›Paper›PMID 38070624›Full record

ArticleBrain, behavior, and immunity2024

Soluble PD-L1 reprograms blood monocytes to prevent cerebral edema and facilitate recovery after ischemic stroke.

Jennifer E Kim, Ryan P Lee, Eli Yazigi, Lyla Atta, James Feghali, Ayush Pant, Aanchal Jain, Idan Levitan, Eileen Kim, Kisha Patel and 18 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain, behavior, and immunity, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 31 citations in OpenAlex.

  1. Trial
  2. Article
  3. Single-cell RNA sequencing in stroke and traumatic brain injury: Current achievements, challenges and future perspectives on transcriptomic profiling.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Injury to repair: Functions of microglia and monocyte-derived cells in ischemic stroke.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2025
    Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Unmasking a Paradox: Roles of the PD-1/PD-L1 Axis in Alzheimer's Disease-Associated Neuroinflammation.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2025
    Review
  18. Review
  19. Article
  20. Therapeutic implications for the PD-1 axis in cerebrovascular injury.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors at 5 institutions in 2 countries.

Jennifer E KimDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, the United States of America.
Ryan P LeeDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, the United States of America.
Eli YazigiDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, the United States of America.
Lyla AttaDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, the United States of America; Center for Computational Biology, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, the United States of America; Medical Scientist Training Program, Johns Hopkins University School of Medicine, Baltimore, MD, the United States of America.
James FeghaliDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, the United States of America.
Ayush PantDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, the United States of America; Medical Scientist Training Program, Johns Hopkins University School of Medicine, Baltimore, MD, the United States of America.
Aanchal JainDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, the United States of America.
Idan LevitanDepartment of Neurosurgery, Rabin Medical Center, Sackler Medical School, Petah Tikva, Israel.
Eileen KimDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, the United States of America.
Kisha PatelDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, the United States of America.
Nivedha KannapadiDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, the United States of America.
Pavan ShahDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, the United States of America.
Adnan BibicF.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, the United States of America; The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, the United States of America.
Zhipeng HouDepartment of Radiology, School of Medicine, Johns Hopkins University, Baltimore, MD, the United States of America.
Justin M CaplanDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, the United States of America.
L Fernando GonzalezDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, the United States of America.
Judy HuangDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, the United States of America.
Risheng XuDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, the United States of America.
Jean FanDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, the United States of America.
Betty TylerDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, the United States of America.
Henry BremDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, the United States of America.
Vassiliki A BoussiotisDivision of Hematology-Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, the United States of America.
Lauren JantzieDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, the United States of America; Departments of Pediatrics, Johns Hopkins University School of Medicine, Maryland, the United States of America; Kennedy Krieger Institute, Maryland, the United States of America; Department of Neurology, Johns Hopkins University School of Medicine, Maryland, the United States of America.
Shenandoah RobinsonDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, the United States of America; Departments of Pediatrics, Johns Hopkins University School of Medicine, Maryland, the United States of America; Kennedy Krieger Institute, Maryland, the United States of America; Department of Neurology, Johns Hopkins University School of Medicine, Maryland, the United States of America.
Raymond C KoehlerDepartments of Anesthesiology and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD, the United States of America.
Michael LimDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, CA, the United States of America.
Rafael J TamargoDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, the United States of America.
Christopher M JacksonDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, the United States of America. Electronic address: cjacks53@jhmi.edu.
Johns Hopkins University · USBeth Israel Deaconess Medical Center · USKennedy Krieger Institute · USRabin Medical Center · ILStanford Medicine · US

Funding

Research Education Program for Residents and Fellows in Neurology - PorrasR25NS065729 · NINDS · JOHNS HOPKINS UNIVERSITY · PI HILLIS, ARGYE E. · 2009 to 2024
$3.3M
Computational methods for delineating subcellular and cellular spatial transcriptional heterogeneity along developmental trajectoriesR35GM142889 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI FAN, JEAN · 2021 to 2025
$2.0M
NIGMS NIH HHS R35 GM142889NINDS NIH HHS R25 NS065729
6 · The paper itself

Abstract

Acute cerebral ischemia triggers a profound inflammatory response. While macrophages polarized to an M2-like phenotype clear debris and facilitate tissue repair, aberrant or prolonged macrophage activation is counterproductive to recovery. The inhibitory immune checkpoint Programmed Cell Death Protein 1 (PD-1) is upregulated on macrophage precursors (monocytes) in the blood after acute cerebrovascular injury. To investigate the therapeutic potential of PD-1 activation, we immunophenotyped circulating monocytes from patients and found that PD-1 expression was upregulated in the acute period after stroke. Murine studies using a temporary middle cerebral artery (MCA) occlusion (MCAO) model showed that intraperitoneal administration of soluble Programmed Death Ligand-1 (sPD-L1) significantly decreased brain edema and improved overall survival. Mice receiving sPD-L1 also had higher performance scores short-term, and more closely resembled sham animals on assessments of long-term functional recovery. These clinical and radiographic benefits were abrogated in global and myeloid-specific PD-1 knockout animals, confirming PD-1+ monocytes as the therapeutic target of sPD-L1. Single-cell RNA sequencing revealed that treatment skewed monocyte maturation to a non-classical Ly6C

Indexed as

Brain EdemaIschemic StrokeAnimalsB7-H1 AntigenHumansInfarction, Middle Cerebral ArteryMiceMonocytesProgrammed Cell Death 1 ReceptorB7-H1 AntigenProgrammed Cell Death 1 ReceptorImmune checkpointsInflammationIschemic strokeLarge vessel occlusionMCAOMonocytessPD-L1

Identifiers

PMID38070624
PMCPMC11220828
OpenAlexW4389454774

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.