Evidence map›Paper›PMID 38070501›Full record

ArticleNeuron2023

Full field-of-view virtual reality goggles for mice.

Domonkos Pinke, John B Issa, Gabriel A Dara, Gergely Dobos, Daniel A Dombeck

Abstract read
In one paragraph

Article in Neuron, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Behavioral Training Procedures for Head-fixed Virtual Reality in Mice.Journal of visualized experiments : JoVE · 2024
    Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Domonkos PinkeDepartment of Neurobiology, Northwestern University, Evanston, IL 60208, USA.
John B IssaDepartment of Neurobiology, Northwestern University, Evanston, IL 60208, USA.
Gabriel A DaraDepartment of Neurobiology, Northwestern University, Evanston, IL 60208, USA.
Gergely Dobos360world Ltd, Sümegvár köz 9, 1118 Budapest, Hungary.
Daniel A DombeckDepartment of Neurobiology, Northwestern University, Evanston, IL 60208, USA. Electronic address: d-dombeck@northwestern.edu.

Funding

Behavioral relevance of active dendritic mechanisms of integration and plasticityR01MH101297 · NIMH · NORTHWESTERN UNIVERSITY · PI DOMBECK, DANIEL A · 2013 to 2023
$4.8M
Training Program in Neurobiology of Information StorageT32MH067564 · NIMH · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Daniel A Dombeck · 2003 to 2026
$4.7M
NIMH NIH HHS R01 MH101297NIMH NIH HHS T32 MH067564
6 · The paper itself

Abstract

Visual virtual reality (VR) systems for head-fixed mice offer advantages over real-world studies for investigating the neural circuitry underlying behavior. However, current VR approaches do not fully cover the visual field of view of mice, do not stereoscopically illuminate the binocular zone, and leave the lab frame visible. To overcome these limitations, we developed iMRSIV (Miniature Rodent Stereo Illumination VR)-VR goggles for mice. Our system is compact, separately illuminates each eye for stereo vision, and provides each eye with an ∼180° field of view, thus excluding the lab frame while accommodating saccades. Mice using iMRSIV while navigating engaged in virtual behaviors more quickly than in a current monitor-based system and displayed freezing and fleeing reactions to overhead looming stimulation. Using iMRSIV with two-photon functional imaging, we found large populations of hippocampal place cells during virtual navigation, global remapping during environment changes, and unique responses of place cell ensembles to overhead looming stimulation.

Indexed as

Spatial NavigationVirtual RealityAnimalsEye Protective DevicesMiceVisual Fieldsgoggleshippocampusimmersionloomingmousenavigationplace cellsspatial behaviorstwo-photon microscopyvirtual reality

Identifiers

PMID38070501
PMCPMC10841834

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.