Evidence map›Paper›PMID 38070406›Full record

ArticleEpilepsy & behavior : E&B2024

Alcohol for seizure induction in the epilepsy monitoring unit.

Brian E Emmert, Kevin Xie, Erin C Conrad, Nina J Ghosn, Kristie Bauman, Jacob Korzun, Catherine V Kulick-Soper, Omer Naveed, Nicole Hartmann, Joshua J LaRocque and 9 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epilepsy & behavior : E&B, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 74% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 2 institutions in 1 country.

Brian E EmmertDepartment of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia PA, USA. Electronic address: Brian.emmert@pennmedicine.upenn.edu.
Kevin XieDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA; Center for Neuroengineering & Therapeutics, University of Pennsylvania, Philadelphia, PA, USA.
Erin C ConradDepartment of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia PA, USA; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA; Center for Neuroengineering & Therapeutics, University of Pennsylvania, Philadelphia, PA, USA.
Nina J GhosnDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA; Center for Neuroengineering & Therapeutics, University of Pennsylvania, Philadelphia, PA, USA.
Kristie BaumanDepartment of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia PA, USA.
Jacob KorzunDepartment of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia PA, USA.
Catherine V Kulick-SoperDepartment of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia PA, USA.
Omer NaveedDepartment of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia PA, USA.
Nicole HartmannDepartment of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia PA, USA.
Joshua J LaRocqueDepartment of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia PA, USA.
Taneeta Mindy GangulyDepartment of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia PA, USA.
James J GuggerDepartment of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia PA, USA; Center for Neuroengineering & Therapeutics, University of Pennsylvania, Philadelphia, PA, USA.
Ramya RaghupathiDepartment of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia PA, USA.
Michael A GelfandDepartment of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia PA, USA.
Kathryn A DavisDepartment of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia PA, USA; Center for Neuroengineering & Therapeutics, University of Pennsylvania, Philadelphia, PA, USA.
Saurabh R SinhaDepartment of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia PA, USA.
Brian LittDepartment of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia PA, USA; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA; Center for Neuroengineering & Therapeutics, University of Pennsylvania, Philadelphia, PA, USA.
Russell T ShinoharaPenn Statistics in Imaging and Visualization Center (PennSIVE), Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia PA, USA; Center for Biomedical Image Computing and Analytics, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia PA, USA.
Colin A EllisDepartment of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia PA, USA.
University of Pennsylvania · USTranslational Therapeutics (United States) · US

Funding

Ghost in the Machine: Melding Brain, Computer and BehaviorDP1NS122038 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI LITT, BRIAN · 2020 to 2024
$5.7M
Training Program in Neuroengineering and MedicineT32NS091006 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI Brian Litt · 2015 to 2026
$4.1M
Quantitative interictal networks to localize seizure generatorsK23NS121401 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI Erin Conrad · 2022 to 2026
$1.2M
Polygenic risk in familial epilepsyK23NS121520 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI ELLIS, COLIN · 2021 to 2025
$1.1M
Neuroimaging Phenotypes of Post-Traumatic EpilepsyK23NS135101 · NINDS · UNIVERSITY OF ROCHESTER · PI James J Gugger · 2024 to 2026
$664k
NINDS NIH HHS DP1 NS122038NINDS NIH HHS K23 NS121401NINDS NIH HHS K23 NS121520NINDS NIH HHS K23 NS135101NINDS NIH HHS T32 NS091006
6 · The paper itself

Abstract

rationaleSeizure induction techniques are used in the epilepsy monitoring unit (EMU) to increase diagnostic yield and reduce length of stay. There are insufficient data on the efficacy of alcohol as an induction technique.

methodsWe performed a retrospective cohort study using six years of EMU data at our institution. We compared cases who received alcohol for seizure induction to matched controls who did not. The groups were matched on the following variables: age, reason for admission, length of stay, number of antiseizure medications (ASM) at admission, whether ASMs were tapered during admission, and presence of interictal epileptiform discharges. We used both propensity score and exact matching strategies. We compared the likelihood of epileptic seizures and nonepileptic events in cases versus controls using Kaplan-Meier time-to-event analysis, as well as odds ratios for these outcomes occurring at any time during the admission.

resultsWe analyzed 256 cases who received alcohol (median dose 2.5 standard drinks) and 256 propensity score-matched controls. Cases who received alcohol were no more likely than controls to have an epileptic seizure (X

conclusionsAlcohol was not an effective induction technique in the EMU. This finding has implications for counseling patients with epilepsy about the risks of drinking alcohol in moderation in their daily lives.

Indexed as

ElectroencephalographyEpilepsyEthanolHumansMonitoring, PhysiologicRetrospective StudiesSeizuresEthanolAlcoholEpilepsy monitoring unitInduction techniques

Identifiers

PMID38070406
PMCPMC10842723
OpenAlexW4389497275

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.