Evidence map›Paper›PMID 38070180›Full record

ArticleCancer medicine2023

Utilization of cardiac tests in anthracycline-treated cancer survivors differs between young adults and children: A claims-based analysis.

Xu Ji, Xin Hu, Joseph Lipscomb, Eric J Chow, Ann C Mertens, Sharon M Castellino

Open access · goldAbstract read
In one paragraph

Article in Cancer medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Xu JiDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID 0000-0003-3025-3984
Xin HuDepartment of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, Virginia, USA.ORCID 0000-0003-1097-3300
Joseph LipscombDepartment of Health Policy and Management, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
Eric J ChowUniversity of Washington School of Medicine and Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Ann C MertensDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
Sharon M CastellinoDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
Emory University · USUniversity of Virginia · USUniversity of Washington · US

Funding

CDC HHS SIP20-004
6 · The paper itself

Abstract

backgroundThe Children's Oncology Group Guidelines recommend a cardiacechocardiogram, or comparable functional imaging, following therapy completion in survivors of childhood/adolescent cancers exposed to anthracyclines.

methodsUsing the 2009-2019 Merative™ MarketScan® Commercial Database, we examined real-world utilization of cardiac testing among 1609 anthracycline-treated survivors of childhood/adolescent cancers.

resultsThe cumulative incidence of receiving an initial cardiac test by 5.25 years from the index date (six months after end-of-therapy) was 62.3% (95% CI = 57.5%-66.7%), with median time to initial test being 2.7 years (95% CI = 2.5%-3.1%). Young adults (18-28 years) were less likely than children (≤17 years) to receive cardiac testing (hazard ratio [HR] = 0.42, 95% CI = 0.3%-0.49%). More likely to receive cardiac testing were survivors receiving hematopoietic stem cell transplantation versus chemotherapy only (HR = 2.23, 95% CI = 1.63%-3.03%), and survivors with bone or soft tissue versus hematologic cancer (HR = 1.64, 95% CI = 1.30%-2.07%).

conclusionsNearly 40% of anthracycline-treated survivors of childhood/adolescent cancers had not received cardiac testing within 5.25 years post-index date, with young adults least likely to receive a test.

Indexed as

Cancer SurvivorsHeart FailureNeoplasmsAdolescentAnthracyclinesAntibiotics, AntineoplasticChildHumansYoung AdultAnthracyclinesAntibiotics, Antineoplasticanthracyclinecardiac testingcommercial claims datasurvivors of childhood and adolescent cancer

Identifiers

PMID38070180
PMCPMC10757126
OpenAlexW4389504247

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.