Evidence map›Paper›PMID 38070135›Full record

ArticleCell reports2023

Ketogenic diet therapy for pediatric epilepsy is associated with alterations in the human gut microbiome that confer seizure resistance in mice.

Gregory R Lum, Sung Min Ha, Christine A Olson, Montgomery Blencowe, Jorge Paramo, Beck Reyes, Joyce H Matsumoto, Xia Yang, Elaine Y Hsiao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 29 citations in OpenAlex.

  1. Trial
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  7. LongitudinalFrontiers in molecular biosciences · 2026
    Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. The Interplay between the Gut and Ketogenic Diets in Health and Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  13. Article
  14. Article
  15. Article
  16. Article
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  18. Observational
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Gregory R LumDepartment of Integrative Biology & Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: glum@g.ucla.edu.
Sung Min HaDepartment of Integrative Biology & Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Christine A OlsonDepartment of Integrative Biology & Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Montgomery BlencoweDepartment of Integrative Biology & Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Jorge ParamoUCLA Goodman-Luskin Microbiome Center, Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, Los Angeles, CA 90095, USA.
Beck ReyesDepartment of Pediatrics, Division of Pediatric Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Joyce H MatsumotoDepartment of Pediatrics, Division of Pediatric Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Xia YangDepartment of Integrative Biology & Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Elaine Y HsiaoDepartment of Integrative Biology & Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA; UCLA Goodman-Luskin Microbiome Center, Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, Los Angeles, CA 90095, USA. Electronic address: ehsiao@g.ucla.edu.
University of California, Los Angeles · US

Funding

Dissecting Microbiota-Gut-Brain Interactions for the Anti-Seizure Effects of the Ketogenic DietR01NS115537 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HSIAO, ELAINE · 2020 to 2024
$1.7M
NINDS NIH HHS R01 NS115537
6 · The paper itself

Abstract

The gut microbiome modulates seizure susceptibility and the anti-seizure effects of the ketogenic diet (KD) in animal models, but whether these relationships translate to KD therapies for human epilepsy is unclear. We find that the clinical KD alters gut microbial function in children with refractory epilepsy. Colonizing mice with KD-associated microbes promotes seizure resistance relative to matched pre-treatment controls. Select metagenomic and metabolomic features, including those related to anaplerosis, fatty acid β-oxidation, and amino acid metabolism, are seen with human KD therapy and preserved upon microbiome transfer to mice. Mice colonized with KD-associated gut microbes exhibit altered hippocampal transcriptomes, including pathways related to ATP synthesis, glutathione metabolism, and oxidative phosphorylation, and are linked to susceptibility genes identified in human epilepsy. Our findings reveal key microbial functions that are altered by KD therapies for pediatric epilepsy and linked to microbiome-induced alterations in brain gene expression and seizure protection in mice.

Indexed as

Diet, KetogenicEpilepsyGastrointestinal MicrobiomeMicrobiotaAnimalsChildDisease Models, AnimalHumansKetone BodiesMiceSeizuresKetone BodiesCP: MicrobiologyCP: Neuroscienceepilepsyketogenic dietmicrobiomeseizure

Identifiers

PMID38070135
PMCPMC10769314
OpenAlexW4389490805

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.