Evidence map›Paper›PMID 38070132›Full record

Trial reportSleep2024

Sleep and insulin sensitivity in adolescents at risk of type 2 diabetes: the Sleep Manipulation in Adolescents at Risk of Type 2 Diabetes randomized crossover study.

Caroline Dutil, Irina Podinic, Ryan B Featherstone, Amelia Eaton, Christin M Sadler, Gary S Goldfield, Stasia Hadjiyannakis, Reut Gruber, Mark S Tremblay, Denis Prud'homme and 1 more

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Sleep, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03754036 (Effect of Increasing Sleep Duration on Insulin Sensitivity in Adolescents Having Risk Factors for Type 2 Diabetes), which is not on this map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03754036 nacompletednot on this map

Effect of Increasing Sleep Duration on Insulin Sensitivity in Adolescents Having Risk Factors for Type 2 Diabetes

TypeinterventionalSponsorChildren's Hospital of Eastern OntarioRan2019 to 2021Enrolled35ConditionsSleepArmsSleep manipulation
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Sleep habits in the pathogenesis and management of diabesity.Journal of diabetes investigation · 2025
    Review
  6. Review
  7. Article
  8. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Caroline DutilHealthy Active Living and Obesity Research Group, Children's Hospital of Eastern Ontario (CHEO) Research Institute, Ottawa, ON, Canada.
Irina PodinicHealthy Active Living and Obesity Research Group, Children's Hospital of Eastern Ontario (CHEO) Research Institute, Ottawa, ON, Canada.
Ryan B FeatherstoneHealthy Active Living and Obesity Research Group, Children's Hospital of Eastern Ontario (CHEO) Research Institute, Ottawa, ON, Canada.
Amelia EatonHealthy Active Living and Obesity Research Group, Children's Hospital of Eastern Ontario (CHEO) Research Institute, Ottawa, ON, Canada.
Christin M SadlerHealthy Active Living and Obesity Research Group, Children's Hospital of Eastern Ontario (CHEO) Research Institute, Ottawa, ON, Canada.
Gary S GoldfieldHealthy Active Living and Obesity Research Group, Children's Hospital of Eastern Ontario (CHEO) Research Institute, Ottawa, ON, Canada.
Stasia HadjiyannakisCentre for Healthy Active Living (CHAL), Children's Hospital of Eastern Ontario (CHEO), Ottawa, ON, Canada.
Reut GruberDepartment of Psychiatry, McGill University, Montreal, QC, Canada.
Mark S TremblayHealthy Active Living and Obesity Research Group, Children's Hospital of Eastern Ontario (CHEO) Research Institute, Ottawa, ON, Canada.
Denis Prud'hommeSchool of Human Kinetics, University of Ottawa, Ottawa, ON, Canada.
Jean-Philippe ChaputHealthy Active Living and Obesity Research Group, Children's Hospital of Eastern Ontario (CHEO) Research Institute, Ottawa, ON, Canada.ORCID 0000-0002-5607-5736
University of Ottawa · CADouglas Mental Health University Institute · CA

Funding

CIHR 425587
6 · The paper itself

Abstract

STUDY

objectivesTo investigate the effect of increasing sleep duration for 1 week, compared to a week of habitual and decreased sleep, on insulin sensitivity (IS) in adolescents at risk for type 2 diabetes (T2D).

methodsAdolescents, 13-18 years old, at risk for T2D, with obesity and other risk factors, were recruited for a randomized (1:1), open-label, sex-stratified crossover study, that manipulated time-in-bed to modify sleep duration (measured by actigraphy). Following a week of habitual (HB) sleep, time-in-bed was increased (IN) and decreased (DE) by 1 hour 30 min/night for 1 week, counterbalanced across participants (HBINDE or HBDEIN), and separated by a week of washout sleep. The main outcome measure was IS, obtained via 2-hour oral-glucose-tolerance-test conducted after each sleep week.

resultsOf the 43 participants recruited, 36 (84%) completed all sleep interventions (52.8% female, age = 15.1 years, body mass index = 99.9th percentile, order: HBINDE = 18 and HBDEIN = 18). On average, during the HB week, participants slept 7 hours 31 min/night; sleep duration was 1 hour 02 min/night higher during the IN week and 1 hour 19 min/night lower during the DE week. We found a significant effect of sleep week on IS with a large effect size. Following the IN sleep week, IS was 20% higher compared to after the HB and DE sleep weeks, but there was no significant difference in IS following HB versus DE sleep weeks.

conclusionsWhenever possible, clinicians should empower youth at risk of T2D to improve their sleep duration, since even a modest increase in sleep duration of 1 h/night for 1 week can have a positive impact on IS in this population. CLINICAL TRIALS: Sleep Extension and IS in Adolescents, https://clinicaltrials.gov/study/NCT03754036, November 23rd, 2018.

trial registrationClinicalTrials.gov (ID:NCT03754036).

Indexed as

Cross-Over StudiesDiabetes Mellitus, Type 2Insulin ResistanceSleepActigraphyAdolescentBlood GlucoseFemaleGlucose Tolerance TestHumansMaleRisk FactorsBlood Glucoseadolescentsexperimental studyinsulin resistanceinsulin sensitivityobesitysleep durationsleep manipulationtype 2 diabetes

Identifiers

PMID38070132
PMCPMC11082473
OpenAlexW4389525205

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.