Evidence map›Paper›PMID 38070098›Full record

ArticleWorld journal of pediatrics : WJP2024

Adrenocorticotropic hormone combined with magnesium sulfate therapy for infantile epileptic spasms syndrome: a real-world study.

Wen He, Qiu-Hong Wang, Jiu-Wei Li, Yang-Yang Wang, Xiao-Mei Luo, Lin Wan, Jing Wang, Xiu-Yu Shi, Wei-Hua Zhang, Fang Fang and 1 more

Open access · hybridAbstract readMulticenter Study
In one paragraph

Article in World journal of pediatrics : WJP, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Wen HeSenior Department of Pediatrics, the Seventh Medical Center of Chinese PLA General Hospital, Department of Pediatrics, the First Medical Center of Chinese PLA General Hospital, Beijing 100853, China.
Qiu-Hong WangSenior Department of Pediatrics, the Seventh Medical Center of Chinese PLA General Hospital, Department of Pediatrics, the First Medical Center of Chinese PLA General Hospital, Beijing 100853, China.
Jiu-Wei LiDepartment of Neurology, Beijing Children's Hospital, Capital Medical University, Beijing, China.
Yang-Yang WangSenior Department of Pediatrics, the Seventh Medical Center of Chinese PLA General Hospital, Department of Pediatrics, the First Medical Center of Chinese PLA General Hospital, Beijing 100853, China.
Xiao-Mei LuoCenter of Epilepsy, Beijing Institute for Brain Disorders, Beijing 100069, China.
Lin WanSenior Department of Pediatrics, the Seventh Medical Center of Chinese PLA General Hospital, Department of Pediatrics, the First Medical Center of Chinese PLA General Hospital, Beijing 100853, China.
Jing WangSenior Department of Pediatrics, the Seventh Medical Center of Chinese PLA General Hospital, Department of Pediatrics, the First Medical Center of Chinese PLA General Hospital, Beijing 100853, China.
Xiu-Yu ShiSenior Department of Pediatrics, the Seventh Medical Center of Chinese PLA General Hospital, Department of Pediatrics, the First Medical Center of Chinese PLA General Hospital, Beijing 100853, China.
Wei-Hua ZhangDepartment of Neurology, Beijing Children's Hospital, Capital Medical University, Beijing, China.
Fang FangDepartment of Neurology, Beijing Children's Hospital, Capital Medical University, Beijing, China. 13910150389@163.com.
Li-Ping ZouSenior Department of Pediatrics, the Seventh Medical Center of Chinese PLA General Hospital, Department of Pediatrics, the First Medical Center of Chinese PLA General Hospital, Beijing 100853, China. zouliping21@sina.com.ORCID 0000-0001-7233-9378
Chinese PLA General Hospital · CNCapital Medical University · CNChinese Institute for Brain Research · CN

Funding

Capital's Funds for Health Improvement and Research No. 2022-1-5081National Key Research and Development Program of China No. 2016YFC1000707
6 · The paper itself

Abstract

backgroundInfantile epileptic spasms syndrome (IESS) is a serious disease in infants, and it usually evolves to other epilepsy types or syndromes, especially refractory or super-refractory focal epilepsies. Although adrenocorticotropic hormone (ACTH) is one of the first-line and effective treatment plans for IESS, it has serious side effects and is not sufficiently effective.

methodsA retrospective study of the clinical outcomes of ACTH combined with magnesium sulfate (MgSO

resultsWe initially recruited 1205 IESS patients from two Chinese hospitals and treated them with ACTH combined with MgSO

conclusionOur findings support that ACTH combined with MgSO

Indexed as

Adrenocorticotropic HormoneDrug Therapy, CombinationMagnesium SulfateSpasms, InfantileAnticonvulsantsChinaCohort StudiesElectroencephalographyFemaleHumansInfantMalePropensity ScoreRetrospective StudiesTreatment OutcomeAdrenocorticotropic HormoneAnticonvulsantsMagnesium SulfateAdrenocorticotropic hormoneClinical trialInfantile epileptic spasms syndromeMagnesium sulfateReal-world study

Identifiers

PMID38070098
PMCPMC11402841
OpenAlexW4389506215

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.