Evidence map›Paper›PMID 38069665›Full record

ArticleEuropean stroke journal2024

Early neurological deterioration in patients with acute ischemic stroke is linked to unfavorable cerebral venous outflow.

Christian Heitkamp, Laurens Winkelmeier, Jeremy J Heit, Gregory W Albers, Maarten G Lansberg, Helge Kniep, Gabriel Broocks, Christian Paul Stracke, Maximilian Schell, Adrien Guenego and 4 more

Abstract readMulticenter Study
In one paragraph

Article in European stroke journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  8. Observational
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  14. Observational
  15. Predictors of futile recanalization in ischemic stroke patients with low baseline NIHSS.International journal of stroke : official journal of the International Stroke Society · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Christian HeitkampDepartment of Neuroradiology, University Medical Center Hamburg-Eppendorf, Germany.ORCID 0000-0002-8988-0918
Laurens WinkelmeierDepartment of Neuroradiology, University Medical Center Hamburg-Eppendorf, Germany.ORCID 0000-0002-9103-5983
Jeremy J HeitDepartment of Radiology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0003-1055-8000
Gregory W AlbersDepartment of Neurology, Stanford University School of Medicine, Stanford, CA, USA.
Maarten G LansbergDepartment of Neurology, Stanford University School of Medicine, Stanford, CA, USA.
Helge KniepDepartment of Neuroradiology, University Medical Center Hamburg-Eppendorf, Germany.
Gabriel BroocksDepartment of Neuroradiology, University Medical Center Hamburg-Eppendorf, Germany.
Christian Paul StrackeDepartment of Neuroradiology, University Medical Center Hamburg-Eppendorf, Germany.
Maximilian SchellDepartment of Neurology, University Medical Center Hamburg-Eppendorf, Germany.ORCID 0000-0002-4631-7519
Adrien GuenegoDepartment of Neuroradiology, Erasme Medical Center, Brussels, Belgium.
Daniel PaechClinic for Neuroradiology, University Hospital Bonn, Germany.
Max WintermarkDepartment of Neuroradiology, MD Anderson, Houston, TX, USA.
Jens FiehlerDepartment of Neuroradiology, University Medical Center Hamburg-Eppendorf, Germany.
Tobias D FaizyDepartment of Neuroradiology, University Medical Center Hamburg-Eppendorf, Germany.ORCID 0000-0002-1631-2020

Funding

NSTN National Clinical Coordinating CenterU01NS086872 · NINDS · UNIVERSITY OF CINCINNATI · PI Joseph Paul Broderick, Pooja Khatri · 2013 to 2026
$32.3M
Workshop to Identify Collaborative Project(s) for the NIH StrokeNet and the Japan NEtwork for Clinical Stroke Trials (NECST)U01NS087748 · NINDS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Catherine R. Dillon, Jordan J. Elm · 2014 to 2026
$14.1M
The Vascular effects of Infection in Pediatric Stroke (VIPS II) StudyR01NS104094 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FULLERTON, HEATHER J · 2017 to 2022
$3.5M
NINDS NIH HHS R01 NS104094NINDS NIH HHS U01 NS086872NINDS NIH HHS U01 NS087748
6 · The paper itself

Abstract

introductionEarly neurological deterioration (END) is associated with poor outcomes in patients with acute ischemic stroke due to large vessel occlusion (AIS-LVO). Causes of END after mechanical thrombectomy (MT) include unsuccessful recanalization and reperfusion hemorrhages. However, little is known about END excluding the aforementioned causes. We aimed to investigate factors associated with unexplained END (END PATIENTS AND

methodsMulticenter retrospective study of AIS-LVO patients with successful MT (mTICI 2b-3). On admission CT angiography (CTA), pial arterial collaterals and venous outflow (VO) were assessed using the modified Tan-Scale and the Cortical Vein Opacification Score (COVES), respectively. END

resultsA total of 620 patients met the inclusion criteria. END DISCUSSION AND

conclusionUnfavorable VO on admission CTA was associated with END

Indexed as

Cerebral VeinsIschemic StrokeStrokeHumansRetrospective StudiesTreatment Outcomeangiographyblood flowCT angiographyStrokethrombectomy

Identifiers

PMID38069665
PMCPMC10916832

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.