ReviewJournal of clinical laboratory analysis2024
The platelet storage lesion, what are we working for?
Review in Journal of clinical laboratory analysis, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Application and retrospective analysis of the indicator system for non-conforming blood products in Beijing.Vox sanguinis · 2026Article
- Selective preservation of shear-dependent platelet adhesion during microvolume storage in a compact agitation system.Research and practice in thrombosis and haemostasis · 2026Article
- Effects of the start date of refrigeration on functions of delayed cold-stored platelets.Vox sanguinis · 2026Article
- The viability and coagulation function of storing platelets can be maintained in plasma without cryoprotectants at -80 °C.Research and practice in thrombosis and haemostasis · 2026Article
- Characterization of Platelet Protein Alterations in Stored Platelet Concentrates.Journal of clinical medicine · 2026Article
- Hijacking the helpers: platelet and neutrophil trafficking in AML and therapeutic exploitation.Experimental hematology & oncology · 2026Review
- Characterization of the in vitro quality parameters of cold-stored platelets containing aggregates.Vox sanguinis · 2025Article
- Impact of pre-analytical variables - temperature, agitation, storage duration, and blood-to-anticoagulant ratio - on complete blood count test reliability.Medicine and pharmacy reports · 2025Article
- Enhanced Quinolone Resistance and Differential Expression of Efflux PumpAntibiotics (Basel, Switzerland) · 2025Article
- GPVI-dependent functional competence of buffy coat platelet concentrates (PCs) versus PRP-derived PCs: insights into the effects of biomechanical forces during platelet preparation.Annals of hematology · 2025Article
- ABO incompatibility and component irradiation are independently associated with platelet transfusion reaction rate.Transfusion · 2025Article
- Establishment of a nomogram-based prognostic model (LASSO-Cox regression) for predicting platelet storage lesions under different storage conditions.Frontiers in molecular biosciences · 2025Article
- Storage damage of cold-stored whole blood in CPDA maintenance fluid during the whole effective storage period.Frontiers in cell and developmental biology · 2025Article
- The platelet storage lesion, what are we working for?Journal of clinical laboratory analysis · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundPlatelet concentrate (PC) transfusions are crucial in prevention and treatment of bleeding in infection, surgery, leukemia, and thrombocytopenia patients. Although the technology for platelet preparation and storage has evolved over the decades, there are still challenges in the demand for platelets in blood banks because the platelet shelf life is limited to 5 days due to bacterial contamination and platelet storage lesions (PSLs) at 20-24°C under constant horizontal agitation. In addition, the relations between some adverse effects of platelet transfusions and PSLs have also been considered. Therefore, understanding the mechanisms of PSLs is conducive to obtaining high quality platelets and facilitating safe and effective platelet transfusions.
objectiveThis review summarizes developments in mechanistic research of PSLs and their relationship with clinical practice, providing insights for future research.
methodsAuthors conducted a search on PubMed and Web of Science using the professional terms "PSL" and "platelet transfusion." The obtained literature was then roughly categorized based on their research content. Similar studies were grouped into the same sections, and further searches were conducted based on the keywords of each section.
resultsDifferent studies have explored PSLs from various perspectives, including changes in platelet morphology, surface molecules, biological response modifiers (BMRs), metabolism, and proteins and RNA, in an attempt to monitor PSLs and identify intervention targets that could alleviate PSLs. Moreover, novel platelet storage conditions, including platelet additive solutions (PAS) and reconsidered cold storage methods, are explored. There are two approaches to obtaining high-quality platelets. One approach simulates the in vivo environment to maintain platelet activity, while the other keeps platelets at a low activity level in vitro under low temperatures.
conclusionUnderstanding PSLs helps us identify good intervention targets and assess the therapeutic effects of different PSLs stages for different patients.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.