Evidence map›Paper›PMID 38069426›Full record

ArticleInternational journal of molecular sciences2023

Elena G Varlamova, Ekaterina V Borisova, Yuliya A Evstratova, Andrew G Newman, Vera P Kuldaeva, Maria S Gavrish, Elena V Kondakova, Victor S Tarabykin, Alexey A Babaev, Egor A Turovsky

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Elena G VarlamovaInstitute of Cell Biophysics of the Russian Academy of Sciences, Federal Research Center "Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences", 142290 Pushchino, Russia.ORCID 0000-0003-1158-5174
Ekaterina V BorisovaInstitute of Cell Biology and Neurobiology, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.
Yuliya A EvstratovaFederal State Budgetary Educational Institution of Higher Education "MIREA-Russian Technological University", 78, Vernadskogo Ave., 119454 Moscow, Russia.
Andrew G NewmanInstitute of Cell Biology and Neurobiology, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.
Vera P KuldaevaInstitute of Neuroscience, Lobachevsky State University of Nizhny Novgorod, 23 Gagarin Ave., 603022 Nizhny Novgorod, Russia.
Maria S GavrishInstitute of Neuroscience, Lobachevsky State University of Nizhny Novgorod, 23 Gagarin Ave., 603022 Nizhny Novgorod, Russia.
Elena V KondakovaInstitute of Neuroscience, Lobachevsky State University of Nizhny Novgorod, 23 Gagarin Ave., 603022 Nizhny Novgorod, Russia.ORCID 0000-0002-6123-8181
Victor S TarabykinInstitute of Cell Biology and Neurobiology, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.
Alexey A BabaevInstitute of Neuroscience, Lobachevsky State University of Nizhny Novgorod, 23 Gagarin Ave., 603022 Nizhny Novgorod, Russia.
Egor A TurovskyInstitute of Cell Biophysics of the Russian Academy of Sciences, Federal Research Center "Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences", 142290 Pushchino, Russia.
Russian Academy of Sciences · RUCharité - Universitätsmedizin Berlin · DEInstitute of Cell Biophysics · RUN. I. Lobachevsky State University of Nizhny Novgorod · RUMIREA - Russian Technological University · RU

Funding

Ministry of science and higher education of the Russian Federation (project №FSWR-2023-0029).
6 · The paper itself

Abstract

Epilepsy is one of the common neurological diseases that affects not only adults but also infants and children. Because epilepsy has been studied for a long time, there are several pharmacologically effective anticonvulsants, which, however, are not suitable as therapy for all patients. The genesis of epilepsy has been extensively investigated in terms of its occurrence after injury and as a concomitant disease with various brain diseases, such as tumors, ischemic events, etc. However, in the last decades, there are multiple reports that both genetic and epigenetic factors play an important role in epileptogenesis. Therefore, there is a need for further identification of genes and loci that can be associated with higher susceptibility to epileptic seizures. Use of mouse knockout models of epileptogenesis is very informative, but it has its limitations. One of them is due to the fact that complete deletion of a gene is not, in many cases, similar to human epilepsy-associated syndromes. Another approach to generating mouse models of epilepsy is N-Ethyl-N-nitrosourea (ENU)-directed mutagenesis. Recently, using this approach, we generated a novel mouse strain,

Indexed as

Epilepsy, ReflexAnimalsAnticonvulsantsBrainChildDisease Models, AnimalEthylnitrosoureaHumansLarge-Conductance Calcium-Activated Potassium ChannelsMiceAnticonvulsantsEthylnitrosoureaLarge-Conductance Calcium-Activated Potassium Channelscalcium ionsepileptiform activitygene expressionmutagenesisneuronsreceptorssignaling

Identifiers

PMID38069426
PMCPMC10707124
OpenAlexW4389311799

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.