Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
1 citing paper in PubMed, 2 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
9 authors at 1 institution in 1 country.
Tsung-Han ChouBascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA.ORCID 0000-0002-1986-6088
Zixuan HaoBascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Diego AlbaBascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA.ORCID 0000-0002-4934-6139
Angelina LazoBascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Gabriele Gallo AfflittoBascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Jeremy D EastwoodBascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Vittorio PorciattiBascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA.ORCID 0000-0002-1592-3532
John GuyBascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Hong YuBascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA.ORCID 0000-0002-1272-4511
University of Miami · US
Funding
Shared Equipment ModuleP30EY014801 · NEI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Dmitry V Ivanov · 2004 to 2026
$12.2M
Mito-Targeted AAV to treat Leber Hereditary Optic Neuropathy caused by ND4 mutationsR24EY028785 · NEI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI LAM, BYRON L, PORCIATTI, VITTORIO · 2019 to 2023
$4.6M
Modification of AdenoAssociated Virus to Deliver DNA Directly to MitochondriaR01EY017141 · NEI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI YU, HONG · 2007 to 2019
$3.4M
Vision Research CoreP30EY021721 · NEI · UNIVERSITY OF FLORIDA · PI HAUSWIRTH, WILLIAM W · 2011 to 2015
$2.8M
Intravenous MitoTargeted AAV9 Gene Therapy for Treatment of Visual Loss and Encephalopathy in Leigh Syndrome and NARPR01EY027414 · NEI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI YU, HONG · 2017 to 2020
Leber's hereditary optic neuropathy (LHON) is a common mitochondrial genetic disease, causing irreversible blindness in young individuals. Current treatments are inadequate, and there is no definitive cure. This study evaluates the effectiveness of delivering wildtype human NADH ubiquinone oxidoreductase subunit 4
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Mitochondrially Targeted Gene Therapy Rescues Visual Loss in a Mouse Model of Leber's Hereditary Optic Neuropathy. · full record | OpenQuestion