Evidence map›Paper›PMID 38069298›Full record

ArticleInternational journal of molecular sciences2023

Ambroxol-Enhanced Frequency and Amplitude of Beating Cilia Controlled by a Voltage-Gated Ca

Takashi Nakahari, Chihiro Suzuki, Kotoku Kawaguchi, Shigekuni Hosogi, Saori Tanaka, Shinji Asano, Toshio Inui, Yoshinori Marunaka

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. PMFrontiers in public health · 2025
    Article
  4. International journal of molecular sciences · 2024
    Article
  5. Ciliary Motility Decreased by a COInternational journal of molecular sciences · 2024
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Takashi NakahariResearch Unit for Epithelial Physiology, Research Organization of Science and Technology, BKC, Ritsumeikan University, Kusatsu 525-8577, Japan.ORCID 0000-0001-7093-5520
Chihiro SuzukiLaboratory of Pharmacotherapy, Faculty of Pharmacy, Osaka Medical and Pharmaceutical University, Takatsuki 569-1094, Japan.
Kotoku KawaguchiDepartment of Molecular Physiology, Faculty of Pharmacy, BKC, Ritsumeikan University, Kusatsu 525-8577, Japan.
Shigekuni HosogiDepartment of Clinical and Translational Physiology, Kyoto Pharmaceutical University, Kyoto 607-8414, Japan.
Saori TanakaLaboratory of Pharmacotherapy, Faculty of Pharmacy, Osaka Medical and Pharmaceutical University, Takatsuki 569-1094, Japan.
Shinji AsanoDepartment of Molecular Physiology, Faculty of Pharmacy, BKC, Ritsumeikan University, Kusatsu 525-8577, Japan.
Toshio InuiSaisei Mirai Clinics, Moriguchi 570-0012, Japan.
Yoshinori MarunakaResearch Unit for Epithelial Physiology, Research Organization of Science and Technology, BKC, Ritsumeikan University, Kusatsu 525-8577, Japan.ORCID 0000-0003-3846-0937
Ritsumeikan University · JPOsaka University of Pharmaceutical Sciences · JPKyoto Pharmaceutical University · JPMirai Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ambroxol (ABX), a frequently prescribed secretolytic agent which enhances the ciliary beat frequency (CBF) and ciliary bend angle (CBA, an index of amplitude) by 30%, activates a voltage-dependent Ca

Indexed as

AmbroxolAnimalsCalciumCells, CulturedCiliaEpithelial CellsHydrogen-Ion ConcentrationLungMiceMice, Inbred CBAAmbroxolCalciumairway ciliated epithelial cells[Ca2+]iCaV1.2cell volumeintracellular Cl− concentrationintracellular pHvoltage-gated Ca2+ channels

Identifiers

PMID38069298
PMCPMC10707002
OpenAlexW4389207110

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.