Evidence map›Paper›PMID 38069275›Full record

ReviewInternational journal of molecular sciences2023

Warm Cells, Hot Mitochondria: Achievements and Problems of Ultralocal Thermometry.

Alexey G Kruglov, Alexey M Romshin, Anna B Nikiforova, Arina Plotnikova, Igor I Vlasov

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Re-Evaluating Hot Mitochondria: Too Slow to Cool.Acta physiologica (Oxford, England) · 2026
    Review
  3. Article
  4. Millikelvin Intracellular Nanothermometry with Nanodiamonds.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  5. Article
  6. Exploring the Frontiers of Cell Temperature Measurement and Thermogenesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Alexey G KruglovInstitute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences, 142290 Pushchino, Russia.ORCID 0000-0001-9215-7387
Alexey M RomshinProkhorov General Physics Institute of the Russian Academy of Sciences, 119991 Moscow, Russia.ORCID 0000-0001-9278-6765
Anna B NikiforovaInstitute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences, 142290 Pushchino, Russia.ORCID 0000-0003-4095-6560
Arina PlotnikovaInstitute for Physics and Engineering in Biomedicine, National Research Nuclear University MEPhI (Moscow Engineering Physics Institute MEPhI), 115409 Moscow, Russia.
Igor I VlasovProkhorov General Physics Institute of the Russian Academy of Sciences, 119991 Moscow, Russia.

Funding

Russian Science Foundation 23-14-00129
6 · The paper itself

Abstract

Temperature is a crucial regulator of the rate and direction of biochemical reactions and cell processes. The recent data indicating the presence of local thermal gradients associated with the sites of high-rate thermogenesis, on the one hand, demonstrate the possibility for the existence of "thermal signaling" in a cell and, on the other, are criticized on the basis of thermodynamic calculations and models. Here, we review the main thermometric techniques and sensors developed for the determination of temperature inside living cells and diverse intracellular compartments. A comparative analysis is conducted of the results obtained using these methods for the cytosol, nucleus, endo-/sarcoplasmic reticulum, and mitochondria, as well as their biological consistency. Special attention is given to the limitations, possible sources of errors and ambiguities of the sensor's responses. The issue of biological temperature limits in cells and organelles is considered. It is concluded that the elaboration of experimental protocols for ultralocal temperature measurements that take into account both the characteristics of biological systems, as well as the properties and limitations of each type of sensor is of critical importance for the generation of reliable results and further progress in this field.

Indexed as

MitochondriaThermometryCytosolHot TemperatureOrganellesTemperaturebioenergeticscell thermogenesisheat productionmitochondriananothermometrysensors

Identifiers

PMID38069275
PMCPMC10707128

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.