Evidence map›Paper›PMID 38069190›Full record

ArticleInternational journal of molecular sciences2023

Enhanced Membrane Incorporation of H289Y Mutant GluK1 Receptors from the Audiogenic Seizure-Prone GASH/Sal Model: Functional and Morphological Impacts on

Sandra M Díaz-Rodríguez, Isabel Ivorra, Javier Espinosa, Celia Vegar, M Javier Herrero-Turrión, Dolores E López, Ricardo Gómez-Nieto, Armando Alberola-Die

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Sandra M Díaz-RodríguezNeuroscience Institute of Castilla y León (INCyL), University of Salamanca, E-37007 Salamanca, Spain.
Isabel IvorraDepartment of Physiology, Genetics and Microbiology, University of Alicante, E-03690 Alicante, Spain.ORCID 0000-0001-5201-6360
Javier EspinosaDepartment of Physiology, Genetics and Microbiology, University of Alicante, E-03690 Alicante, Spain.
Celia VegarDepartment of Physiology, Genetics and Microbiology, University of Alicante, E-03690 Alicante, Spain.
M Javier Herrero-TurriónNeuroscience Institute of Castilla y León (INCyL), University of Salamanca, E-37007 Salamanca, Spain.ORCID 0000-0003-3350-2608
Dolores E LópezNeuroscience Institute of Castilla y León (INCyL), University of Salamanca, E-37007 Salamanca, Spain.ORCID 0000-0002-1450-7246
Ricardo Gómez-NietoNeuroscience Institute of Castilla y León (INCyL), University of Salamanca, E-37007 Salamanca, Spain.ORCID 0000-0002-8972-6822
Armando Alberola-DieDepartment of Physiology, Genetics and Microbiology, University of Alicante, E-03690 Alicante, Spain.ORCID 0000-0001-5391-5739
Universidad de Salamanca · ESUniversity of Alicante · ES

Funding

Junta de Castilla y León predoctoral research fellowship 2019 from JCyL (BOCYL, EDU/556/2019)Junta de Castilla y León SA075P20,cofinacied 514 by "ERDF A way of making Europe"University of Alicante VIGROB-058.
6 · The paper itself

Abstract

Epilepsy is a neurological disorder characterized by abnormal neuronal excitability, with glutamate playing a key role as the predominant excitatory neurotransmitter involved in seizures. Animal models of epilepsy are crucial in advancing epilepsy research by faithfully replicating the diverse symptoms of this disorder. In particular, the GASH/Sal (genetically audiogenic seizure-prone hamster from Salamanca) model exhibits seizures resembling human generalized tonic-clonic convulsions. A single nucleotide polymorphism (SNP; C9586732T, p.His289Tyr) in the

Indexed as

Epilepsy, ReflexAnimalsCricetinaeHumansKainic Acid ReceptorsOocytesSeizuresXenopus laevisKainic Acid Receptorsepilepsygenetic variantGluK1kainate currentsmembrane incorporationXenopus oocytes

Identifiers

PMID38069190
PMCPMC10706347
OpenAlexW4389086839

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.