Evidence map›Paper›PMID 38069071›Full record

ArticleInternational journal of molecular sciences2023

Osteogenic Potential of Human Dental Pulp Stem Cells (hDPSCs) Growing on Poly L-Lactide-Co-Caprolactone and Hyaluronic Acid (HYAFF-11

Julia K Bar, Anna Lis-Nawara, Tomasz Kowalczyk, Piotr G Grelewski, Sandra Stamnitz, Hanna Gerber, Aleksandra Klimczak

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Julia K BarDepartment of Immunopathology and Molecular Biology, Wroclaw Medical University, Borowska 211, 50-556 Wroclaw, Poland.
Anna Lis-NawaraDepartment of Immunopathology and Molecular Biology, Wroclaw Medical University, Borowska 211, 50-556 Wroclaw, Poland.
Tomasz KowalczykLaboratory of Polymers and Biomaterials, Institute of Fundamental Technological Research (IPPT PAN), Polish Academy of Sciences, Adolfa Pawińskiego 5B St., 02-106 Warsaw, Poland.
Piotr G GrelewskiDepartment of Immunopathology and Molecular Biology, Wroclaw Medical University, Borowska 211, 50-556 Wroclaw, Poland.ORCID 0000-0002-4955-2370
Sandra StamnitzLaboratory of Biology of Stem and Neoplastic Cells, Hirszfeld Institute of Immunology and Experimental Therapy Polish Academy of Sciences, R. Weigla 12, 53-114 Wroclaw, Poland.
Hanna GerberDepartment of Maxillofacial Surgery, Wroclaw Medical University, Borowska 213, 50-556Wroclaw, Poland.
Aleksandra KlimczakLaboratory of Biology of Stem and Neoplastic Cells, Hirszfeld Institute of Immunology and Experimental Therapy Polish Academy of Sciences, R. Weigla 12, 53-114 Wroclaw, Poland.ORCID 0000-0001-6590-4420
Wroclaw Medical University · PLLudwik Hirszfeld Institute of Immunology and Experimental Therapy · PLInstitute of Fundamental Technological Research · PL

Funding

Wroclaw Medical University grant No. SIMPLE-SUBZ.A353.23.087
6 · The paper itself

Abstract

Bone tissue engineering using different scaffolds is a new therapeutic approach in regenerative medicine. This study explored the osteogenic potential of human dental pulp stem cells (hDPSCs) grown on a hydrolytically modified poly(L-lactide-co-caprolactone) (PLCL) electrospun scaffold and a non-woven hyaluronic acid (HYAFF-11™) mesh. The adhesion, immunophenotype, and osteogenic differentiation of hDPSCs seeded on PLCL and HYAFF-11™ scaffolds were analyzed. The results showed that PLCL and HYAFF-11™ scaffolds significantly supported hDPSCs adhesion; however, hDPSCs' adhesion rate was significantly higher on PLCL than on HYAFF-11™. SEM analysis confirmed good adhesion of hDPSCs on both scaffolds before and after osteogenesis. Alizarin red S staining showed mineral deposits on both scaffolds after hDPSCs osteogenesis. The mRNA levels of

Indexed as

OsteogenesisTissue ScaffoldsCaproatesCell DifferentiationCell ProliferationCells, CulturedDental PulpDioxanesHumansHyaluronic AcidLactonesMineralsRNA, MessengerStem CellsCaproatescaprolactonedilactideDioxanesHyaluronic Acidhyaluronic acid benzyl esterLactonesMineralsRNA, Messengerdental stem cellshDPSCsHYAFF-11 scaffoldosteogenesisPLCL scaffold

Identifiers

PMID38069071
PMCPMC10705868
OpenAlexW4389051633

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.