Evidence map›Paper›PMID 38069069›Full record

ArticleInternational journal of molecular sciences2023

New Insights via RNA Profiling of Formalin-Fixed Paraffin-Embedded Lung Tissue of Pulmonary Fibrosis Patients.

Dymph Klay, Karin M Kazemier, Joanne J van der Vis, Hidde M Smits, Jan C Grutters, Coline H M van Moorsel

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Dymph KlayInterstitial Lung Diseases Center of Excellence, Department of Pulmonology, St. Antonius Hospital, 3435 CM Nieuwegein, The Netherlands.ORCID 0000-0003-0519-1769
Karin M KazemierCenter of Translational Immunology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.
Joanne J van der VisInterstitial Lung Diseases Center of Excellence, Department of Pulmonology, St. Antonius Hospital, 3435 CM Nieuwegein, The Netherlands.ORCID 0000-0002-6727-8416
Hidde M SmitsCenter of Translational Immunology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.ORCID 0009-0008-9621-4797
Jan C GruttersInterstitial Lung Diseases Center of Excellence, Department of Pulmonology, St. Antonius Hospital, 3435 CM Nieuwegein, The Netherlands.
Coline H M van MoorselInterstitial Lung Diseases Center of Excellence, Department of Pulmonology, St. Antonius Hospital, 3435 CM Nieuwegein, The Netherlands.
St. Antonius Ziekenhuis · NLUniversity Medical Center Utrecht · NL

Funding

Prof. Dr. Jaap Swierenga foundationZonMW-TopZorg St Antonius Science Corner 842002001ZonMW TZO vision grant 1007001201000
6 · The paper itself

Abstract

In sporadic idiopathic pulmonary fibrosis (sIPF) and pulmonary fibrosis caused by a mutation in telomere (TRG-PF) or surfactant related genes (SRG-PF), there are a number of aberrant cellular processes known that can lead to fibrogenesis. We investigated whether RNA expression of genes involved in these processes differed between sIPF, TRG-PF, and SRG-PF and whether expression levels were associated with survival. RNA expression of 28 genes was measured in lung biopsies of 26 sIPF, 17 TRG-PF, and 6 SRG-PF patients. Significant differences in RNA expression of

Indexed as

Idiopathic Pulmonary FibrosisRNAEndoplasmic Reticulum Chaperone BiPFormaldehydeHumansLungParaffin EmbeddingEndoplasmic Reticulum Chaperone BiPFormaldehydeRNAidiopathic pulmonary fibrosislung tissueRNA expressionRTEL1SFTPA2SFTPCsurfactant related gene mutationtelomere related gene mutationTERT

Identifiers

PMID38069069
PMCPMC10706203
OpenAlexW4389051582

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.