Evidence map›Paper›PMID 38069046›Full record

ArticleInternational journal of molecular sciences2023

Enhancing the Antimicrobial Properties of Peptides through Cell-Penetrating Peptide Conjugation: A Comprehensive Assessment.

Sergey V Kravchenko, Pavel A Domnin, Sergei Y Grishin, Nikita A Vershinin, Elena V Gurina, Anastasiia A Zakharova, Viacheslav N Azev, Leila G Mustaeva, Elena Y Gorbunova, Margarita I Kobyakova and 5 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 1 country.

Sergey V KravchenkoInstitute of Environmental and Agricultural Biology (X-BIO), Tyumen State University, 625003 Tyumen, Russia.ORCID 0000-0002-1261-7919
Pavel A DomninBiology Faculty, Lomonosov Moscow State University, 119991 Moscow, Russia.
Sergei Y GrishinInstitute of Environmental and Agricultural Biology (X-BIO), Tyumen State University, 625003 Tyumen, Russia.ORCID 0000-0001-7373-9808
Nikita A VershininInstitute of Environmental and Agricultural Biology (X-BIO), Tyumen State University, 625003 Tyumen, Russia.
Elena V GurinaInstitute of Environmental and Agricultural Biology (X-BIO), Tyumen State University, 625003 Tyumen, Russia.
Anastasiia A ZakharovaInstitute of Cytology, Russian Academy of Sciences, 194064 St. Petersburg, Russia.
Viacheslav N AzevThe Branch of the Institute of Bioorganic Chemistry, Russian Academy of Sciences, 142290 Pushchino, Russia.ORCID 0000-0003-3275-4811
Leila G MustaevaThe Branch of the Institute of Bioorganic Chemistry, Russian Academy of Sciences, 142290 Pushchino, Russia.
Elena Y GorbunovaThe Branch of the Institute of Bioorganic Chemistry, Russian Academy of Sciences, 142290 Pushchino, Russia.
Margarita I KobyakovaInstitute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, 142290 Pushchino, Russia.ORCID 0000-0002-6846-9994
Alexey K SurinInstitute of Protein Research, Russian Academy of Sciences, 142290 Pushchino, Russia.
Roman S FadeevInstitute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, 142290 Pushchino, Russia.
Olga S OstroumovaInstitute of Cytology, Russian Academy of Sciences, 194064 St. Petersburg, Russia.
Svetlana A ErmolaevaGamaleya Research Centre of Epidemiology and Microbiology, 123098 Moscow, Russia.ORCID 0000-0003-3396-6816
Oxana V GalzitskayaInstitute of Protein Research, Russian Academy of Sciences, 142290 Pushchino, Russia.ORCID 0000-0002-3962-1520
Institute of Bioorganic Chemistry · RUUniversity of Tyumen · RUInstitute of Cytology · RUInstitute of Theoretical and Experimental Biophysics · RUGamalei Institute of Epidemiology and Microbiology · RULomonosov Moscow State University · RURussian Academy of Sciences · RU

Funding

Russian Science Foundation 18-14-00321
6 · The paper itself

Abstract

Combining antimicrobial peptides (AMPs) with cell-penetrating peptides (CPPs) has shown promise in boosting antimicrobial potency, especially against Gram-negative bacteria. We examined the CPP-AMP interaction with distinct bacterial types based on cell wall differences. Our investigation focused on AMPs incorporating penetratin CPP and dihybrid peptides containing both cell-penetrating TAT protein fragments from the human immunodeficiency virus and Antennapedia peptide (Antp). Assessment of the peptides TAT-AMP, AMP-Antp, and TAT-AMP-Antp revealed their potential against Gram-positive strains (

Indexed as

Anti-Infective AgentsCell-Penetrating PeptidesMethicillin-Resistant Staphylococcus aureusAnti-Bacterial AgentsEscherichia coliHumansMicrobial Sensitivity TestsRibosomal ProteinsStaphylococcus aureusAnti-Bacterial AgentsAnti-Infective AgentsCell-Penetrating PeptidesRibosomal ProteinsamyloidAntennapedia peptideantimicrobial peptidescell-penetrating peptideFoldAmyloidribosomal S1 proteinTAT fragment

Identifiers

PMID38069046
PMCPMC10706425
OpenAlexW4388970973

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.