Evidence map›Paper›PMID 38069020›Full record

ArticleInternational journal of molecular sciences2023

HLA-E and Its Soluble Form as Indicators of a Sex-Specific Immune Response in Patients with Oral Squamous Cell Carcinoma.

Anne Radermacher, Michael Fehrenz, Tamara Bellin, Carolina Claßen, Laura Möller, Ann-Kristin Struckmeier, Mathias Wagner, Philipp Wartenberg, Julius Moratin, Christian Freudlsperger and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Anne RadermacherDentistry, Stomatology and Orthodontics, Chair of Oral and Maxillofacial Surgery, Saarland University, 66421 Homburg, Germany.
Michael FehrenzDepartment of Oral and Maxillofacial Surgery, Saarland University, 66421 Homburg, Germany.
Tamara BellinDepartment of Oral and Maxillofacial Surgery, Saarland University, 66421 Homburg, Germany.ORCID 0009-0001-1784-9508
Carolina ClaßenDepartment of Oral and Maxillofacial Surgery, Saarland University, 66421 Homburg, Germany.
Laura MöllerDentistry, Stomatology and Orthodontics, Chair of Oral and Maxillofacial Surgery, Saarland University, 66421 Homburg, Germany.
Ann-Kristin StruckmeierDepartment of Oral and Maxillofacial Surgery, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
Mathias WagnerDepartment of Pathology, Saarland University Medical Center, 66421 Homburg, Germany.
Philipp WartenbergDepartment of Experimental and Clinical Pharmacology and Toxicology, Center for Molecular Signaling (PZMS), Saarland University, 66421 Homburg, Germany.
Julius MoratinDepartment of Oral and Maxillofacial Surgery, University Hospital Heidelberg, 69120 Heidelberg, Germany.ORCID 0000-0002-0278-7228
Christian FreudlspergerDepartment of Oral and Maxillofacial Surgery, University Hospital Heidelberg, 69120 Heidelberg, Germany.ORCID 0000-0002-4289-0457
Kolja FreierDepartment of Oral and Maxillofacial Surgery, Saarland University, 66421 Homburg, Germany.
Dominik HornDepartment of Oral and Maxillofacial Surgery, Saarland University, 66421 Homburg, Germany.
Saarland University · DEHeidelberg University · DEFriedrich-Alexander-Universität Erlangen-Nürnberg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The human leukocyte antigene E (HLA-E) is associated with tumorigenesis in various cancers. Immunoncology along with sex-specific aspects in cancer therapy are now in scientific focus. Therefore, immunohistochemical HLA-E expression was retrospectively analysed in a cohort of oral squamous cell carcinomas (OSCC) after surgical therapy. Then, serum concentration of HLA-E (sHLA-E) was quantified in a prospective cohort by enzyme-linked immunosorbent assay. High HLA-E expression was associated with advanced UICC stage (Spearman's correlation:

Indexed as

Carcinoma, Squamous CellHead and Neck NeoplasmsMouth NeoplasmsFemaleHistocompatibility Antigens Class IHLA-G AntigensHumansImmunityMaleProspective StudiesRetrospective StudiesSquamous Cell Carcinoma of Head and NeckHistocompatibility Antigens Class IHLA-G AntigensHLA-Eimmunotherapyoral squamous cell carcinoma (OSCC)sex-related differences in immune responsesoluble HLA-E

Identifiers

PMID38069020
PMCPMC10706335
OpenAlexW4388974664

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.