Evidence map›Paper›PMID 38068962›Full record

ArticleInternational journal of molecular sciences2023

Pyruvate Kinase Differentially Alters Metabolic Signatures during Head and Neck Carcinogenesis.

Pei-Chun Huang, Ching-Wen Chang, Yu-Cheng Lin, Chang-Yi Chen, Tsai-Ying Chen, Lu-Te Chuang, Chung-Ji Liu, Chien-Ling Huang, Wan-Chun Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Metabolic-epigenetic reprogrammingActa pharmaceutica Sinica. B · 2026
    Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Pei-Chun HuangInstitute of Oral Biology, College of Dentistry, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan.
Ching-Wen ChangGraduate Institute of Metabolism and Obesity Sciences (GIMOS), College of Nutrition, Taipei Medical University, Taipei 11031, Taiwan.
Yu-Cheng LinDepartment of Dentistry, College of Dentistry, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan.ORCID 0000-0002-4787-2565
Chang-Yi ChenInstitute of Oral Biology, College of Dentistry, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan.
Tsai-Ying ChenInstitute of Oral Biology, College of Dentistry, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan.
Lu-Te ChuangDepartment of Biotechnology and Pharmaceutical Technology, Yuanpei University of Medical Technology, Hsinchu 30015, Taiwan.ORCID 0000-0002-0318-0030
Chung-Ji LiuDepartment of Dentistry, College of Dentistry, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan.ORCID 0000-0002-0385-869X
Chien-Ling HuangDepartment of Health Technology and Informatics (HTI), The Hong Kong Polytechnic University (PolyU), Hung Hom, Kowloon, Hong Kong SAR, China.ORCID 0000-0002-6396-5649
Wan-Chun LiInstitute of Oral Biology, College of Dentistry, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan.ORCID 0000-0003-0481-4215
National Yang Ming Chiao Tung University · TWHong Kong Polytechnic University · HKTaipei Medical University · TWYuanpei University · TW

Funding

National Science and Technology Council 103-2314-B-010-024-MY3, 106-2314-B-010-005-MY3, 109-2628-B-010-008-, 110-2628-B-A49A-511-, 110-2314-B-A49A-516-MY3
6 · The paper itself

Abstract

During glycolysis, the muscle isoform of pyruvate kinase PKM2 produces ATP in exchange for dephosphorylation of phosphoenolpyruvate (PEP) into pyruvate. PKM2 has been considered as a tumor-promoting factor in most cancers, whereas the regulatory role of PKM2 during head and neck carcinogenesis remained to be delineated. PKM2 mRNA and protein expression was examined in head and neck tumorous specimens. The role of PKM2 in controlling cellular malignancy was determined in shRNA-mediated PKM2-deficient head and neck squamous cell carcinoma (HNSC) cells. In agreement with the results in other cancers, PKM2 expression is enriched in both mouse and human HNSC tissues. Nevertheless, PKM2 mRNA expression reversely correlated with tumor stage, and greater recurrence-free survival rates are evident in the PKM2

Indexed as

Head and Neck NeoplasmsPyruvate KinaseAnimalsCarcinogenesisCell Line, TumorCisplatinGlycolysisHumansMiceRNA, MessengerSquamous Cell Carcinoma of Head and NeckCisplatinPKM2 protein, humanPyruvate KinaseRNA, Messengerglycolytic ATPhead and neck cancermetabolic reprogrammingpyruvate kinase M2 form

Identifiers

PMID38068962
PMCPMC10706023
OpenAlexW4388928930

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.