Evidence map›Paper›PMID 38068942›Full record

ArticleInternational journal of molecular sciences2023

Nanodiamond Effects on Cancer Cell Radiosensitivity: The Interplay between Their Chemical/Physical Characteristics and the Irradiation Energy.

Veronica Varzi, Emiliano Fratini, Mauro Falconieri, Daniela Giovannini, Alessia Cemmi, Jessica Scifo, Ilaria Di Sarcina, Pietro Aprà, Sofia Sturari, Lorenzo Mino and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 1 country.

Veronica VarziPhysics Department, National Institute of Nuclear Physics, Section of Turin, University of Turin, Via P. Giuria 1, 10125 Turin, Italy.ORCID 0000-0001-7609-1576
Emiliano FratiniLaboratory of Biomedical Technologies, Italian National Agency for New Technologies, Energy and Sustainable Economic Development (ENEA), Casaccia Research Centre, Via Anguillarese 301, 00123 Rome, Italy.ORCID 0000-0003-2522-1718
Mauro FalconieriFusion and Technology for Nuclear Safety and Security Department, Italian National Agency for New Technologies, Energy and Sustainable Economic Development (ENEA), Casaccia Research Centre, Via Anguillarese 301, 00123 Rome, Italy.ORCID 0000-0001-5184-4834
Daniela GiovanniniLaboratory of Biomedical Technologies, Italian National Agency for New Technologies, Energy and Sustainable Economic Development (ENEA), Casaccia Research Centre, Via Anguillarese 301, 00123 Rome, Italy.
Alessia CemmiInnovative Nuclear Systems Laboratory, Italian National Agency for New Technologies, Energy and Sustainable Economic Development (ENEA), Casaccia Research Centre, Via Anguillarese 301, 00123 Rome, Italy.ORCID 0000-0002-5626-6778
Jessica ScifoInnovative Nuclear Systems Laboratory, Italian National Agency for New Technologies, Energy and Sustainable Economic Development (ENEA), Casaccia Research Centre, Via Anguillarese 301, 00123 Rome, Italy.ORCID 0000-0002-7595-6125
Ilaria Di SarcinaInnovative Nuclear Systems Laboratory, Italian National Agency for New Technologies, Energy and Sustainable Economic Development (ENEA), Casaccia Research Centre, Via Anguillarese 301, 00123 Rome, Italy.
Pietro ApràPhysics Department, National Institute of Nuclear Physics, Section of Turin, University of Turin, Via P. Giuria 1, 10125 Turin, Italy.
Sofia SturariPhysics Department, National Institute of Nuclear Physics, Section of Turin, University of Turin, Via P. Giuria 1, 10125 Turin, Italy.
Lorenzo MinoNanomaterials for Industry and Sustainability (NIS) Inter-Departmental Centre, University of Turin, Via Quarello 15/A, 10125 Turin, Italy.ORCID 0000-0002-9882-8361
Giulia TomagraDrug Science and Technology Department, University of Turin, Corso Raffaello 30, 10125 Turin, Italy.ORCID 0000-0003-2090-3402
Erminia InfusinoMedical Physics Laboratory, IRCCS Istituto Nazionale Tumori Regina Elena, Via Elio Chianesi 53, 00144 Rome, Italy.
Valeria LandoniMedical Physics Laboratory, IRCCS Istituto Nazionale Tumori Regina Elena, Via Elio Chianesi 53, 00144 Rome, Italy.ORCID 0000-0003-1160-3985
Carmela MarinoLaboratory of Biomedical Technologies, Italian National Agency for New Technologies, Energy and Sustainable Economic Development (ENEA), Casaccia Research Centre, Via Anguillarese 301, 00123 Rome, Italy.
Mariateresa MancusoLaboratory of Biomedical Technologies, Italian National Agency for New Technologies, Energy and Sustainable Economic Development (ENEA), Casaccia Research Centre, Via Anguillarese 301, 00123 Rome, Italy.ORCID 0000-0002-0912-9287
Federico PicolloPhysics Department, National Institute of Nuclear Physics, Section of Turin, University of Turin, Via P. Giuria 1, 10125 Turin, Italy.ORCID 0000-0003-3179-271X
Simonetta PazzagliaLaboratory of Biomedical Technologies, Italian National Agency for New Technologies, Energy and Sustainable Economic Development (ENEA), Casaccia Research Centre, Via Anguillarese 301, 00123 Rome, Italy.
National Agency for New Technologies, Energy and Sustainable Economic Development · ITUniversity of Turin · ITIstituti di Ricovero e Cura a Carattere Scientifico · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nanoparticles are being increasingly studied to enhance radiation effects. Among them, nanodiamonds (NDs) are taken into great consideration due to their low toxicity, inertness, chemical stability, and the possibility of surface functionalization. The objective of this study is to explore the influence of the chemical/physical properties of NDs on cellular radiosensitivity to combined treatments with radiation beams of different energies. DAOY, a human radioresistant medulloblastoma cell line was treated with NDs-differing for surface modifications [hydrogenated (H-NDs) and oxidized (OX-NDs)], size, and concentration-and analysed for (i) ND internalization and intracellular localization, (ii) clonogenic survival after combined treatment with different radiation beam energies and (iii) DNA damage and apoptosis, to explore the nature of ND-radiation biological interactions. Results show that chemical/physical characteristics of NDs are crucial in determining cell toxicity, with hydrogenated NDs (H-NDs) decreasing either cellular viability when administered alone, or cell survival when combined with radiation, depending on ND size and concentration, while OX-NDs do not. Also, irradiation at high energy (γ-rays at 1.25 MeV), in combination with H-NDs, is more efficient in eliciting radiosensitisation when compared to irradiation at lower energy (X-rays at 250 kVp). Finally, the molecular mechanisms of ND radiosensitisation was addressed, demonstrating that cell killing is mediated by the induction of Caspase-3-dependent apoptosis that is independent to DNA damage. Identifying the optimal combination of ND characteristics and radiation energy has the potential to offer a promising therapeutic strategy for tackling radioresistant cancers using H-NDs in conjunction with high-energy radiation.

Indexed as

NanodiamondsNeoplasmsCell SurvivalHumansRadiation ToleranceNanodiamondsapoptosisDNA damagemedulloblastomananodiamondsradiation sensitizerradiation therapy

Identifiers

PMID38068942
PMCPMC10706717
OpenAlexW4388913218

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.