Evidence map›Paper›PMID 38068938›Full record

ArticleInternational journal of molecular sciences2023

Discovery of Anti-Coronavirus Cinnamoyl Triterpenoids Isolated from

Malak Al Ibrahim, Zachee Louis Evariste Akissi, Lowiese Desmarets, Gabriel Lefèvre, Jennifer Samaillie, Imelda Raczkiewicz, Sevser Sahpaz, Jean Dubuisson, Sandrine Belouzard, Céline Rivière and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Malak Al IbrahimUniversity of Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019-UMR9017-Center for Infection and Immunity of Lille (CIIL), F-59000 Lille, France.ORCID 0000-0002-8801-5228
Zachee Louis Evariste AkissiBioEcoAgro, Joint Research Unit 1158, University of Lille, INRAE, University of. Liège, UPJV, YNCREA, University of Artois, University Littoral Côte d'Opale, ICV-Institut Charles Viollette, F-59650 Villeneuve d'Ascq, France.ORCID 0009-0000-6339-2660
Lowiese DesmaretsUniversity of Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019-UMR9017-Center for Infection and Immunity of Lille (CIIL), F-59000 Lille, France.
Gabriel LefèvreBioEcoAgro, Joint Research Unit 1158, University of Lille, INRAE, University of. Liège, UPJV, YNCREA, University of Artois, University Littoral Côte d'Opale, ICV-Institut Charles Viollette, F-59650 Villeneuve d'Ascq, France.
Jennifer SamaillieBioEcoAgro, Joint Research Unit 1158, University of Lille, INRAE, University of. Liège, UPJV, YNCREA, University of Artois, University Littoral Côte d'Opale, ICV-Institut Charles Viollette, F-59650 Villeneuve d'Ascq, France.
Imelda RaczkiewiczUniversity of Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019-UMR9017-Center for Infection and Immunity of Lille (CIIL), F-59000 Lille, France.
Sevser SahpazBioEcoAgro, Joint Research Unit 1158, University of Lille, INRAE, University of. Liège, UPJV, YNCREA, University of Artois, University Littoral Côte d'Opale, ICV-Institut Charles Viollette, F-59650 Villeneuve d'Ascq, France.ORCID 0000-0002-4006-4012
Jean DubuissonUniversity of Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019-UMR9017-Center for Infection and Immunity of Lille (CIIL), F-59000 Lille, France.ORCID 0000-0003-1626-7693
Sandrine BelouzardUniversity of Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019-UMR9017-Center for Infection and Immunity of Lille (CIIL), F-59000 Lille, France.
Céline RivièreBioEcoAgro, Joint Research Unit 1158, University of Lille, INRAE, University of. Liège, UPJV, YNCREA, University of Artois, University Littoral Côte d'Opale, ICV-Institut Charles Viollette, F-59650 Villeneuve d'Ascq, France.ORCID 0000-0002-8618-5530
Karin SéronUniversity of Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019-UMR9017-Center for Infection and Immunity of Lille (CIIL), F-59000 Lille, France.ORCID 0000-0002-9667-133X
Centre National de la Recherche Scientifique · FRUniversité de Lille · FR

Funding

Centre National de la Recherche Scientifique VirocribEuropean Union's Horizon 2020 000FEDER-FSE Hauts-de-France Region AP09 REACT-EU 22003058French state and Région Hauts de France CPER BiHauts Eco de FranceI-Site ULNE under the Marie Sklodowska-Curie grant agreement-PEARL 847568
6 · The paper itself

Abstract

The limited availability of antiviral therapy for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spurred the search for novel antiviral drugs. Here, we investigated the potential antiviral properties of plants adapted to high-salt environments collected in the north of France. Twenty-five crude methanolic extracts obtained from twenty-two plant species were evaluated for their cytotoxicity and antiviral effectiveness against coronaviruses HCoV-229E and SARS-CoV-2. Then, a bioguided fractionation approach was employed. The most active crude methanolic extracts were partitioned into three different sub-extracts. Notably, the dichloromethane sub-extract of the whole plant

Indexed as

Coronavirus 229E, HumanHippophaeOleanolic AcidTriterpenesAntiviral AgentsNorth SeaSalt-Tolerant PlantsSARS-CoV-2Antiviral AgentsOleanolic AcidTriterpenesantiviral agentshalophytesHCoV-229EHippophae rhamnoidesSARS-CoV-2triterpenoids

Identifiers

PMID38068938
PMCPMC10705938
OpenAlexW4388902052

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.