ArticleInternational journal of molecular sciences2023
The Subtype Selectivity in Search of Potent Hypotensive Agents among 5,5-Dimethylhydantoin Derived α
Aneta Kaczor, Joanna Knutelska, Katarzyna Kucwaj-Brysz, Małgorzata Zygmunt, Ewa Żesławska, Agata Siwek, Marek Bednarski, Sabina Podlewska, Magdalena Jastrzębska-Więsek, Wojciech Nitek and 2 more
Open access · goldAbstract read
In one paragraphArticle in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 2 citations in OpenAlex.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
12 authors at 2 institutions in 1 country.
Aneta KaczorDepartment of Technology and Biotechnology of Drugs, Medical College, Jagiellonian University, Medyczna 9, 30-688 Krakow, Poland.
Joanna KnutelskaDepartment of Pharmacodynamics, Medical College, Jagiellonian University, Medyczna 9, 30-688 Krakow, Poland.
Katarzyna Kucwaj-BryszDepartment of Technology and Biotechnology of Drugs, Medical College, Jagiellonian University, Medyczna 9, 30-688 Krakow, Poland.ORCID 0000-0003-4408-9804 Małgorzata ZygmuntDepartment of Pharmacodynamics, Medical College, Jagiellonian University, Medyczna 9, 30-688 Krakow, Poland.
Ewa ŻesławskaInstitute of Biology and Earth Sciences, University of the National Education Commision, Podchorążych 2, 30-084 Krakow, Poland.ORCID 0000-0003-1946-9370 Agata SiwekDepartment of Pharmacobiology, Medical College, Jagiellonian University, Medyczna 9, 30-688 Krakow, Poland.
Marek BednarskiDepartment of Pharmacodynamics, Medical College, Jagiellonian University, Medyczna 9, 30-688 Krakow, Poland.
Sabina PodlewskaMaj Institute of Pharmacology, Polish Academy of Sciences, Department of Medicinal Chemistry, Smętna 12, 31-343 Krakow, Poland.ORCID 0000-0002-2891-5603 Magdalena Jastrzębska-WięsekDepartment of Clinical Pharmacy, Medical College, Jagiellonian University, Medyczna 9, 30-688 Krakow, Poland.ORCID 0000-0002-5388-1214 Wojciech NitekFaculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387 Krakow, Poland.
Jacek SapaDepartment of Pharmacodynamics, Medical College, Jagiellonian University, Medyczna 9, 30-688 Krakow, Poland.
Jadwiga HandzlikDepartment of Technology and Biotechnology of Drugs, Medical College, Jagiellonian University, Medyczna 9, 30-688 Krakow, Poland.ORCID 0000-0002-3674-3581 Jagiellonian University · PLMaj Institute of Pharmacology · PL
Funding
Jagiellonian University N42/DBS/000330Jagiellonian University N42/DBS/000331Pedagogical University of Kraków BN.711-56/PBU/2021
6 · The paper itselfAbstract
In order to find new hypotensive drugs possessing higher activity and better selectivity, a new series of fifteen 5,5-dimethylhydantoin derivatives (
Indexed as
HypotensionPrazosinAdrenergic alpha-1 Receptor AntagonistsAnimalsAntihypertensive AgentsHydantoinsRadioligand AssayRatsReceptors, Adrenergic, alpha-15,5-dimethylhydantoinAdrenergic alpha-1 Receptor AntagonistsAntihypertensive AgentsHydantoinsPrazosinReceptors, Adrenergic, alpha-15,5-dimethylhydantoincrystallographymolecular modellingα1Aα1-adrenoceptorα1B
Identifiers
PMID38068933
PMCPMC10706087
OpenAlexW4388906370
What OpenQuestion holds
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LicenceCC BY
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