Evidence map›Paper›PMID 38068807›Full record

ArticleNutrients2023

Metabolomic Alterations of Volatile Organic Compounds and Bile Acids as Biomarkers of Microbial Shifts in a Murine Model of Short Bowel Syndrome.

Vanessa Wolfschluckner, Beate Obermüller, Angela Horvath, Giovanny Rodriguez-Blanco, Patricia Fuchs, Wolfram Miekisch, Barbara Mittl, Christina Flucher, Holger Till, Georg Singer

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Vanessa WolfschlucknerDepartment of Paediatric and Adolescent Surgery, Medical University of Graz, 8036 Graz, Austria.
Beate ObermüllerDepartment of Paediatric and Adolescent Surgery, Medical University of Graz, 8036 Graz, Austria.ORCID 0000-0002-1610-7916
Angela HorvathDivision of Gastroenterology and Hepatology, Medical University of Graz, 8036 Graz, Austria.ORCID 0000-0001-7279-0628
Giovanny Rodriguez-BlancoClinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, 8036 Graz, Austria.
Patricia FuchsDepartment of Anaesthesiology, Intensive Care and Pain Therapy, Rostock University Medical Center, 18057 Rostock, Germany.ORCID 0000-0002-0055-6098
Wolfram MiekischDepartment of Anaesthesiology, Intensive Care and Pain Therapy, Rostock University Medical Center, 18057 Rostock, Germany.ORCID 0000-0003-1619-0315
Barbara MittlDepartment of Paediatric and Adolescent Surgery, Medical University of Graz, 8036 Graz, Austria.
Christina FlucherDepartment of Paediatric and Adolescent Surgery, Medical University of Graz, 8036 Graz, Austria.
Holger TillDepartment of Paediatric and Adolescent Surgery, Medical University of Graz, 8036 Graz, Austria.
Georg SingerDepartment of Paediatric and Adolescent Surgery, Medical University of Graz, 8036 Graz, Austria.ORCID 0000-0003-4770-3144
Medical University of Graz · ATUniversity of Rostock · DE

Funding

Doctoral School "Molecular Medicine and Inflammation" of the Medical University of Graz no grant number
6 · The paper itself

Abstract

Pediatric short bowel syndrome (SBS) is a rare condition characterized by a massive loss of the small intestine, leading to the inability to meet nutritional requirements without the use of parenteral or enteral supplementation. SBS causes profound alterations in the intestinal microbiome and metabolome. The aim of this study was a detailed assessment of the intestinal microbiome and metabolome in a murine model of SBS. We performed a 60% proximal small bowel resection versus a sham operation in C57BL/6 mice. Four weeks postoperatively, the microbial communities of different intestinal segments (jejunum, ileum, colon) and stool were assessed by 16S rRNA gene sequencing. Bile acids in serum and stool and volatile organic compounds (VOCs) in the fecal headspace were assessed using LC-MS and GC-MS techniques. The α-diversity of the different intestinal segments did not significantly differ between the two groups. β-diversity significantly differed between sham and SBS mice. While in the jejunum,

Indexed as

Short Bowel SyndromeVolatile Organic CompoundsAnimalsBile Acids and SaltsBiomarkersChildDisease Models, AnimalHumansMiceMice, Inbred C57BLRNA, Ribosomal, 16SBile Acids and SaltsBiomarkersRNA, Ribosomal, 16SVolatile Organic Compounds16S rRNA gene sequencingbowel resectionintestinal segmentsmicemicrobiome

Identifiers

PMID38068807
PMCPMC10708115
OpenAlexW4389144228

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.