Evidence map›Paper›PMID 38068528›Full record

ArticleJournal of clinical medicine2023

Nephrological Complications in Hemoglobinopathies: SITE Good Practice.

Giovan Battista Ruffo, Rodolfo Russo, Tommaso Casini, Letizia Lombardini, Valeria Orecchia, Vincenzo Voi, Raffaella Origa, Gian Luca Forni, Monia Marchetti, Antonia Gigante and 3 more

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Guideline
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 10 institutions in 1 country.

Giovan Battista RuffoU.O. Ematologia con Talassemia, ARNAS Civico Di Cristina Benfratelli, 90127 Palermo, Italy.
Rodolfo RussoIRCSS AOU San Martino, Università degli Studi di Genova, 16146 Genova, Italy.
Tommaso CasiniCentro Talassemie Ed Emoglobinopatie, Ospedale "Meyer", 50139 Firenze, Italy.ORCID 0000-0002-0087-5355
Letizia LombardiniCentro Nazionale Trapianti, Istituto Superiore di Sanità, 00161 Roma, Italy.
Valeria OrecchiaClinica Pediatrica, Thalassemia e Malattie Rare, "Microcitemico A. Cao", 09121 Cagliari, Italy.
Vincenzo VoiDipartimento di Scienze Cliniche e Biologiche, Centro delle Emoglobinopatie, Università di Torino, Ospedale San Luigi Gonzaga, 10125 Torino, Italy.ORCID 0000-0001-7249-2735
Raffaella OrigaTalassemia, Ospedale Pediatrico Microcitemico 'A. Cao', ASL8, Università di Cagliari, 09121 Cagliari, Italy.ORCID 0000-0002-2346-9616
Gian Luca ForniEmatologia Centro della Microcitemia e delle Anemie Congenite-E.O. Ospedali Galliera, 16128 Genova, Italy.
Monia MarchettiHematology Unit, Azienda Ospedaliera Ss Antonio e Biagio e Cesare Arrigo, 15121 Alessandria, Italy.ORCID 0000-0001-7615-0572
Antonia GiganteSocietà Italiana Talassemie d Emoglobinopatie (SITE), Fondazione per la Ricerca sulle Anemie ed Emoglobinopatie in Italia-For Anemia, 16124 Genoa, Italy.
Giacomo GaribottoDipartimento di Medicina Interna, Università degli Studi di Genova, 16132 Genova, Italy.ORCID 0000-0001-6432-2429
Aurelio MaggioUnità Operativa Complessa Ematologia per le Malattie Rare del Sangue e degli Organi Ematopoietici, Azienda Ospedaliera Ospedali Riuniti Villa Sofia-V., 90146 Palermo, Italy.
Lucia De FranceschiDipartimento di Medicina, Università degli Studi di Verona-Azienda Ospedeliera Verona, 37124 Verona, Italy.ORCID 0000-0001-7093-777X
Ospedale Microcitemico · ITUniversity of Genoa · ITAzienda di Rilievo Nazionale ed Alta Specializzazione · ITAzienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo · ITEnte Ospedaliero Ospedali Galliera · ITIstituto Superiore di Sanità · ITMeyer Children's Hospital · ITOspedale San Luigi Gonzaga · ITOspedale Vincenzo Cervello · ITUniversity of Verona · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHemoglobinopathies, among which thalassemic syndromes (transfusion-dependent and non-transfusion dependent thalassemias) and sickle cell disease (SCD), are the most widespread monogenic diseases worldwide. Hemoglobinopathies are endemic and spread-out all-over Italy, as result of internal and external migration flows. Nowadays, the increase therapeutic options associated to the general aging of patients with hemoglobinopathies related to the improvement in clinical management, contribute to the abnormalities in kidney function going from blood and urine test alterations to chronic kidney disease and end stage renal disease.

methodsHere, we carried out a revision of the literature as panel of recognized experts in hemoglobinopathies with the consultancy and the revision of two nephrologists on kidney alteration and kidney disease in patients with TDT, NTDT and SCD. This is part of the action of the Italian society for the study of thalassemia and hemoglobinopties (SITE). The purpose of this "good practice (GP)" is to provide recommendations for follow-up and therapy for the management of kidney alterations in patients with TDT, NTDT and SCD. The literature review covers the period 1.1.2016 to 31.12.2022. In consideration of the rarity of these diseases, the analysis was extended from 5 to 7 years. Moreover, in the absence of relevant scientific papers in the identified time frame, we referred to pivotal or population studies, when available. Finally, in the absence of evidence-based data from prospective and randomized trials, the authors had to refer to expert opinion (expert consensus) for many topics.

resultsWe generated question and answer boxes to offer a friendly consultation, using color code strategy and focused answers.

conclusionsThe present GP will help in improving the clinical management, and the quality of care of patients with hemoglobinopathies.

Indexed as

dynamic programminghedgingpost-decision state variablerisk managementtransaction costs

Identifiers

PMID38068528
PMCPMC10707125
OpenAlexW4389263890

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.