ArticleJournal of clinical medicine2023
Spinal Involvement in Patients with Chronic Non-Bacterial Osteomyelitis (CNO): An Analysis of Distinctive Imaging Features.
Article in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Atypical and less-common imaging presentations of chronic nonbacterial osteitis in children: a pictorial review.Pediatric radiology · 2026Review
- Ustekinumab as a novel treatment of chronic nonbacterial osteomyelitis: a case report.AME case reports · 2026Article
- Surgical Interventions in Chronic Recurrent Multifocal Osteomyelitis Affecting the Spine: A Case Report with Literature Review.Journal of orthopaedic case reports · 2025Article
- Vertebral fractures and bone health in patients with chronic non-bacterial osteomyelitis at disease onset: insights from the monocentric CAMELOT cohort.Therapeutic advances in musculoskeletal disease · 2025Article
- Anti-Osteoporosis Is Imperative in Prevention of Progress of Ankylosing Spondylitis.International journal of general medicine · 2025Article
- Chronic nonbacterial osteomyelitis in neuroradiology - behavior and evolution of vertebral and mandibular lesions on imaging.Pediatric radiology · 2024Article
- Imaging of primary vertebral tumors and tumor-like lesions in skeletally immature patients: a pictorial review.Radiologia brasileiraReview
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spinal involvement by chronic non-bacterial osteomyelitis (CNO) has been increasingly reported in recent years, often being presented as a diagnostic dilemma requiring differential diagnosis with bacterial spondylodiscitis and/or neoplasia. This study was aimed at identifying the imaging features of CNO facilitating its differentiation from other spinal diseases. Two radiologists assessed the imaging studies of 45 patients (16 male and 29 female, aged from 6 to 75 years, 15 children) with CNO collected from 5 referential centers. Spinal lesions were found in 17 patients (2 children and 15 adults), most often in the thoracic spine. In children, the lesions involved short segments with a destruction of vertebral bodies. In adults, the main findings were prominent bone marrow edema and osteosclerosis, endplate irregularities, and ankylosing lesions extending over long segments; paraspinal inflammation was mild and abscesses were not observed. In both children and adults, the involvement of posterior elements (costovertebral and facet joints) emerged as an important discriminator between CNO and neoplasia/other inflammatory conditions. In conclusion, a careful inspection of imaging studies may help to reduce the number of biopsies performed in the diagnostic process of CNO.
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