Evidence map›Paper›PMID 38068416›Full record

ArticleJournal of clinical medicine2023

The Compensation Index Is Better Associated with DSA ASITN Collateral Score Compared to the Cerebral Blood Volume Index and Hypoperfusion Intensity Ratio.

Dhairya A Lakhani, Aneri B Balar, Manisha Koneru, Sijin Wen, Meisam Hoseinyazdi, Cynthia Greene, Risheng Xu, Licia Luna, Justin Caplan, Adam A Dmytriw and 10 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Observational
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
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  9. Perfusion imaging parameters predict long-term clinical outcome in isolated posterior cerebral artery occlusion stroke patients.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025
    Article
  10. Review
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  15. Article
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  17. Article
  18. Prolonged Venous Transit Is Associated With Unfavorable Outcomes in Anterior Circulation Distal Medium Vessel Stroke.Journal of neuroimaging : official journal of the American Society of Neuroimaging
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 8 institutions in 2 countries.

Dhairya A LakhaniDepartment of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD 21218, USA.ORCID 0000-0001-7577-1887
Aneri B BalarDepartment of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD 21218, USA.
Manisha KoneruCooper Medical School, Rowan University, Camden, NJ 08028, USA.
Sijin WenDepartment of Biostatistics, West Virginia University, Morgantown, WV 26506, USA.
Meisam HoseinyazdiDepartment of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD 21218, USA.
Cynthia GreeneDepartment of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD 21218, USA.
Risheng XuDepartment of Neurosurgery, Johns Hopkins University, Baltimore, MD 21218, USA.
Licia LunaDepartment of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD 21218, USA.
Justin CaplanDepartment of Neurosurgery, Johns Hopkins University, Baltimore, MD 21218, USA.
Adam A DmytriwDepartment of Radiology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0003-0131-5699
Adrien GuenegoDepartment of Radiology, Université Libre De Bruxelles Hospital Erasme, 1070 Anderlecht, Belgium.
Max WintermarkDepartment of Radiology, University of Texas, MD Anderson Center, Houston, TX 77030, USA.
Fernando GonzalezDepartment of Neurosurgery, Johns Hopkins University, Baltimore, MD 21218, USA.
Victor UrrutiaDepartment of Neurology, Johns Hopkins University, Baltimore, MD 21218, USA.
Judy HuangDepartment of Neurosurgery, Johns Hopkins University, Baltimore, MD 21218, USA.
Kambiz NaelDivision of Neuroradiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0002-4194-9488
Ansaar T RaiDepartment of Radiology, West Virginia University, Morgantown, WV 26506, USA.
Gregory W AlbersDepartment of Radiology, Stanford University School of Medicine, Stanford, CA 94063, USA.
Jeremy J HeitDepartment of Radiology, Stanford University School of Medicine, Stanford, CA 94063, USA.
Vivek S YedavalliDepartment of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD 21218, USA.ORCID 0000-0002-2450-4014
Johns Hopkins University · USStanford University · USWest Virginia University · USCooper Medical School of Rowan University · USHarvard University · USThe University of Texas MD Anderson Cancer Center · USUniversité Libre de Bruxelles · BEUniversity of California, Los Angeles · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPretreatment CT Perfusion (CTP) parameters serve as reliable surrogates of collateral status (CS). In this study, we aim to assess the relationship between the novel compensation index (CI, Tmax > 4 s/Tmax > 6 s) and already established CTP collateral markers, namely cerebral blood volume (CBV) index and Hypoperfusion Intensity Ratio (HIR), with the reference standard American Society of Interventional and Therapeutic Neuroradiology (ASITN) collateral score (CS) on DSA.

methodsIn this retrospective study, inclusion criteria were the following: (a) CT angiography confirmed anterior circulation large vessel occlusion from 9 January 2017 to 10 January 2023; (b) diagnostic CT perfusion; and (c) underwent mechanical thrombectomy with documented DSA-CS. Student

resultsIn total, 223 patients (mean age: 67.8 ± 15.8, 56% female) met our inclusion criteria. The CI (ρ = 0.37,

conclusionCI demonstrates a stronger correlation with DSA-CS compared to both the HIR and CBV Index where it may show promise as an additional quantitative pretreatment CS biomarker.

Indexed as

acute ischemic strokeCBV indexcollateral statuscompensation indexHIRhypoperfusion intensity ratio

Identifiers

PMID38068416
PMCPMC10707013
OpenAlexW4389085146

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.