Evidence map›Paper›PMID 38068373›Full record

ArticleJournal of clinical medicine2023

A Modified Technique for Two-Stage Revision in Knee PJI Treatment.

Raffaele Iorio, Ferdinando Iannotti, Leonardo Previ, Edoardo Viglietta, Yuri Gugliotta, Federico Corsetti, Simone Fenucci, Angelo De Carli, Pier Francesco Indelli, Andrea Redler

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PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Raffaele IorioOrthopaedic Unit, S. Andrea Hospital, University of Rome, "La Sapienza" Via Di Grottarossa 1035, 00189 Rome, Italy.
Ferdinando IannottiDivision Orthopaedic Surgery, Ospedale San Paolo, 00053 Civitavecchia, Italy.ORCID 0000-0003-0988-5258
Leonardo PreviOrthopaedic Unit, S. Andrea Hospital, University of Rome, "La Sapienza" Via Di Grottarossa 1035, 00189 Rome, Italy.
Edoardo VigliettaOrthopaedic Unit, S. Andrea Hospital, University of Rome, "La Sapienza" Via Di Grottarossa 1035, 00189 Rome, Italy.
Yuri GugliottaOrthopaedic Unit, S. Andrea Hospital, University of Rome, "La Sapienza" Via Di Grottarossa 1035, 00189 Rome, Italy.
Federico CorsettiOrthopaedic Unit, S. Andrea Hospital, University of Rome, "La Sapienza" Via Di Grottarossa 1035, 00189 Rome, Italy.
Simone FenucciOrthopaedic Unit, S. Andrea Hospital, University of Rome, "La Sapienza" Via Di Grottarossa 1035, 00189 Rome, Italy.
Angelo De CarliOrthopaedic Unit, S. Andrea Hospital, University of Rome, "La Sapienza" Via Di Grottarossa 1035, 00189 Rome, Italy.ORCID 0000-0003-3918-4313
Pier Francesco IndelliDepartment of Orthopedic Surgery, Stanford University of School of Medicine, Stanford, CA 94063, USA.
Andrea RedlerOrthopaedic Unit, S. Andrea Hospital, University of Rome, "La Sapienza" Via Di Grottarossa 1035, 00189 Rome, Italy.
Sapienza University of Rome · ITOspedale San Paolo · ITStanford University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Knee PJIs represent one of the most important complications after joint replacement surgery. If the prerequisites for implant retention do not subsist, the surgical treatment of these conditions is performed using one-stage and two-stage revision techniques. In this study, an implemented two-stage revision technique was performed, adopting antibiotic calcium sulfate beads and tumor-like debridement guided by methylene blue, such as described for the DAPRI technique. The aim of the present study is to compare the implemented two-stage revision technique with the standard technique in order to assess its effectiveness.

methodsTwenty patients affected by knee PJIs were prospectively enrolled in the study and underwent an implemented two-stage revision technique (Group A). Data collected and clinical results were compared with a matched control group treated with a standard two-stage technique (Group B). For each patient, the time of the reimplantation and length of antibiotic systemic therapy were recorded. Each patient underwent routine laboratory tests, including inflammatory markers.

resultsIn Group A and in Group B, inflammatory markers normalized at 6.5 ± 1.1. weeks and 11.1 ± 2.3 weeks, respectively ( DISCUSSION: The implemented two-stage revision technique demonstrated a faster normalization of inflammatory markers, as well as a decrease in reimplantation time and duration of antibiotic therapy, compared to the traditional technique. The use of calcium sulfate antibiotic beads and tumor-like debridement seems to improve the results and reduce the time of healing.

conclusionThe implemented two-stage revision technique seems to improve the results and reduce the time of healing. This leads to a more rapid and less stressful course for the patient, as well as a reduction in health care costs.

Indexed as

DAPRI techniqueperiprosthetic joint infectionrevision total knee arthroplastytwo-stage revision

Identifiers

PMID38068373
PMCPMC10707302
OpenAlexW4389049903

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.